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. Author manuscript; available in PMC: 2013 Jul 9.
Published in final edited form as: Immunol Res. 2008;41(3):295–309. doi: 10.1007/s12026-008-8039-8

Fig. 1.

Fig. 1

DCs and MΦs repress antibody secretion from autoreactive B cells via IL-6 and sCD40L. (a) In non-autoimmune mice, B cell tolerance is maintained during innate immune responses by DCs and MΦs. Although TLR stimulation promotes Ig secretion by B cells, it simultaneously induces DCs and MΦs to secrete IL-6 and sCD40L. These soluble factors repress Ig secretion from autoreactive B cells while allowing innate stimuli to produce a polyclonal response by naïve B cells. (b) In lupus-prone mice, DCs and MΦs are defective in the production of IL-6 and sCD40L, allowing both autoreactive and naïve B cells to produce Ig in response to TLR stimulation