Table 5.
Association of cytokine with genotype and disease status.
| Cytokine | SNP | Cytokine levels for different genotypes |
p-Value (effect on cytokine) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Genotype | Mean | Genotype | Mean | Genotype | Mean | Genotype | Disease status | ||
| IL-6 | rs1800797 | G | 0.872 | AG | 1.737 | A | 2.005 | 0.0398 | 0.0781 |
| IL-1α | rs1800587 | C | 1.000 | CT | 1.493 | T | 2.756 | 0.0638 | 0.0139 |
| IL-1β | rs1143634 | T | 2.151 | CT | 1.914 | C | 1.298 | 0.2441 | 0.0197 |
| IL-1β | rs1143627 | A | 1.075 | AG | 1.692 | G | 1.294 | 0.4550 | 0.0051 |
| IL-1β | rs16944 | A | 1.294 | AG | 1.750 | G | 1.075 | 0.3893 | 0.0036 |
| IL-10 | rs1800896 | G | 3.657 | AG | 3.022 | A | 2.496 | 0.1644 | 0.3623 |
| IL-10 | rs1800890 | T | 4.075 | AT | 3.102 | A | 2.377 | 0.0222 | 0.3632 |
| IL-10 | rs1800872 | C | 2.970 | AC | 2.800 | A | 2.926 | 0.9087 | 0.1905 |
| IL-10 | rs1800871 | C | 2.995 | CT | 2.640 | T | 2.926 | 0.6571 | 0.1420 |
| IL-2 | rs2069762 | T | 2.401 | GT | 1.705 | G | 1.949 | 0.4029 | 0.1620 |
| IL-13 | rs20541 | C | 4.028 | CT | 4.760 | T | 4.471 | 0.2604 | 0.2036 |
| IL-13 | rs1800925 | T | 5.045 | CT | 4.426 | C | 4.285 | 0.5398 | 0.4403 |
| IL-4 | rs2243248 | T | 2.502 | GT | 2.482 | G | 2.805 | 0.9709 | 0.1453 |
| IL-4 | rs2243250 | T | 2.008 | CT | 3.086 | C | 2.186 | 0.1286 | 0.0745 |
| IFN-γ | rs2069705 | C | 3.257 | CT | 2.439 | T | 3.016 | 0.2776 | 0.2080 |
| IL-5 | rs2069812 | C | 1.839 | CT | 1.847 | T | 1.383 | 0.5136 | 0.0057 |
| TNF-α | rs361525 | G | 1.308 | AG | 0.602 | A | 0.3897 | 0.0086 | |
| TNF-α | rs1800629 | G | 1.413 | AG | 0.879 | A | 0.1412 | 0.0014 | |
| TNF-β | rs909253 | C | 1.180 | CT | 1.139 | T | 1.549 | 0.6004 | 0.0079 |
| IL-17 | rs3819025 | G | 0.584 | AG | 0.492 | A | 0.394 | 0.0048 | 0.4463 |
| IL-12 | rs2243113 | G | AG | 1.280 | A | 1.216 | 0.7108 | 0.1053 | |
| IL-8 | rs2227306 | T | 1.848 | CT | 1.992 | C | 1.985 | 0.8105 | 0.0989 |
| IL-8 | rs4073 | T | 1.957 | AT | 2.059 | A | 1.792 | 0.4522 | 0.0680 |