Table 3.

Empirically derived cut points for cognitive screening measures as compared to impairment on the full neuropsychological battery^*

	PDQ-SF, ≥10	3 screening cognitive tests, ≥1 impaired at –1 SD	Phonemic fluency, ≤34	HVLT-R learning, ≤26	HVLT-R delay, ≤9
Total group
Sensitivity (95% CI)	0.55 (0.38–0.70)	0.74 (0.58–0.86)	0.79 (0.63–0.89)	0.74 (0.58–0.86)	0.67 (0.50–0.80)
Specificity (95% CI)	0.73 (0.66–0.79)	0.65 (0.57–0.72)	0.66 (0.58–0.72)	0.65 (0.57–0.72)	0.70 (0.62–0.76)
PPV (95% CI)	0.32 (0.26–0.39)	0.34 (0.24–0.44)	0.35 (0.26–0.46)	0.35 (0.24–0.44)	0.35 (0.25–0.46)
NPV (95% CI)	0.87 (0.80–0.92)	0.91 (0.84–0.95)	0.93 (0.86–0.96)	0.92 (0.84–0.95)	0.90 (0.83–0.94)
% correctly classified	69	67	68	67	70
SLE
Sensitivity (95% CI)	0.62 (0.44–0.77)	0.77 (0.58–0.89)	0.79 (0.62–0.91)	0.74 (0.55–0.86)	0.47 (0.30–0.65)
Specificity (95% CI)	0.65 (0.54–0.74)	0.65 (0.54–0.74)	0.67 (0.56–0.76)	0.68 (0.57–0.77)	0.85 (0.76–0.91)
PPV (95% CI)	0.38 (0.25–0.51)	0.43 (0.30–0.56)	0.45 (0.32–0.58)	0.43 (0.31–0.58)	0.52 (0.34–0.69)
NPV (95% CI)	0.83 (0.73–0.91)	0.89 (0.79–0.95)	0.92 (0.81–0.96)	0.89 (0.78–0.94)	0.82 (0.73–0.89)
% correctly classified	64	67	70	69	75
RA
Sensitivity (95% CI)	0.25 (0.04–0.64)	0.63 (0.26–0.90)	0.86 (0.43–0.99)	0.75 (0.36–0.96)	0.75 (0.36–0.96)
Specificity (95% CI)	0.84 (0.73–0.91)	0.65 (0.53–0.76)	0.64 (0.52–0.75)	0.61 (0.49–0.72)	0.77 (0.66–0.86)
PPV (95% CI)	0.14 (0.03–0.44)	0.16 (0.06–0.34)	0.18 (0.07–0.36)	0.17 (0.07–0.34)	0.26 (0.11–0.48)
NPV (95% CI)	0.91 (0.81–0.96)	0.94 (0.83–0.99)	0.98 (0.88–0.99)	0.96 (0.85–0.95)	0.97 (0.87–0.99)
% correctly classified	78	65	66	63	77

^*PDQ-SF = Perceived Deficits Questionnaire-Short Form; HVLT-R = Hopkins Verbal Learning Test-Revised; 95% CI = 95% confidence interval; PPV = positive predictive value; NPV = negative predictive value; SLE = systemic lupus erythematosus; RA = rheumatoid arthritis.