Figure 3.
Sorted hESC-RG cells are multipotent in vitro. (A) BrdU incorporation after 2 DIV* in proliferation medium. (B–F) In differentiation medium hESC-RG cells generate mainly mature-looking GFAP+ astrocytes (B), neurons labeled with β-III-tubulin (C), DCX+ (D) or MAP2 antibody (E), and rarely PDGFR-α+ oligodendrocyte progenitors (F). (G) Quantification of hESC-RG progeny after 7 DIV* in differentiation medium. Data represent three independent experiments. ***p < 0.0001. Nuclei were stained with bisbenzamide (Blue). Scale bars: 50μm, 10μm.