Table 2.
Hierarchical Logistic Regression Evaluating Cardiovascular Risk Factors and Events as Predictors of Cognitive Dysfunction
| Adjusted Models? | ||||
|---|---|---|---|---|
|
n=694
observations |
Unadjusted Model |
Model 1a | Model 2b | Model 3c |
| OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| Disease Activity (SLAQ) |
1.08 (1.05-1.11) | 1.04 (1.01-1.07) | 1.04 (1.00- 1.07) |
1.04 (1.00-1.07) |
| Disease Duration | 0.98 (0.95-1.00) | 0.98 (0.95-1.01) | 0.97 (0.94- 1.00) |
0.97 (0.94-1.00) |
| Antiphospholipid antibodies |
1.94 (1.28-2.94) | 2.14 (1.34-3.41) |
2.24 (1.39-
3.61) |
2.10 (1.3-3.41) |
| Hypertension | 1.98 (1.26-3.09) |
2.08 (1.21-
3.58) |
2.06 (1.19-3.56) | |
| Hyperlipidemia | 1.02 (0.67-1.55) | 0.81 (0.49- 1.35) |
0.74 (0.43-1.26) | |
| Diabetes | 1.81 (1.02-3.21) | 1.35 (0.66- 2.76) |
1.24 (0.6-2.57) | |
| Obese | 1.44 (0.93-2.24) | 0.68 (0.39- 1.17) |
0.71 (0.41-1.24) | |
| Current smoking | 2.56 (1.41-4.63) | 1.47 (0.73- 2.95) |
1.51 (0.74-3.07) | |
| Myocardial Infarction |
1.37 (0.64-2.92) | 0.96 (0.38-2.44) | ||
| Stroke | 2.62 (1.50-4.58) | 2.27 (1.16-4.43) | ||
?
All models adjusted for gender, education, poverty status, and depression.
a
Model 1: Disease-related variables.
b
Model 2: Disease-related variables and cardiovascular risk-factors.
c
Model 3: Disease-related variables, cardiovascular risk-factors and events.
All variables are self-reported with the exception of presence of antiphospholipid antibodies and disease duration which were collected from chart review.