Table 2.
Hemodynamic parameters and indexes of systolic and diastolic function derived from right ventricular pressure-volume relationships in CTL, HPH, and HPH + CP mice
|
Room Air 21% O2 |
Acute Hypoxia 8% O2 |
|||||
|---|---|---|---|---|---|---|
| CTL | HPH | CP | CTL | HPH | CP | |
| Heart rate (beats/min) | 598 ± 8 | 598 ± 10 | 572 ± 12 | 573 ± 9 | 575 ± 10 | 552 ± 14 |
| Aortic peak systolic pressure (mm Hg) | 78 ± 4 | 81 ± 5 | 76 ± 3 | 72 ± 9 | 71 ± 12 | 73 ± 6 |
| RV peak systolic pressure (mm Hg) | 29.8 ± 1.2 | 38.9 ± 1.0 b | 34.9 ± 1.2 a | 28.6 ± 1.8 | 41.0 ± 1.5 b | 34.5 ± 1.2 b , a |
| RV end-diastolic volume (μl) | 24.6 ± 0.9 | 24.9 ± 1.8 | 23.7 ± 1.9 | 33.8 ± 6.6 | 24.9 ± 3.3 b | 17.6 ± 1.6 b |
| Cardiac output (ml/min) | 8.5 ± 0.3 | 8.0 ± 0.6 | 7.8 ± 0.4 | 4.6 ± 0.7 c | 5.2 ± 0.5 c | 5.1 ± 0.5 c |
| RV ejection fraction (%) | 58.0 ± 2.5 | 54.8 ± 3.3 | 60.2 ± 4.5 | 27.9 ± 5.4 c | 38.2 ± 3.6 c | 54.8 ± 4.6 b , a |
| Total pulmonary vascular resistance (mm Hg-min/ml) | 3.5 ± 0.2 | 5.3 ± 0.4 b | 4.6 ± 0.4 | 6.4 ± 0.9 c | 9.7 ± 0.8 b , c | 5.7 ± 1.0 a , c |
| RV dP/dtmax (mm Hg/s) | 2720 ± 141 | 3638 ± 78 b | 3103 ± 97 a | 2080 ± 165 | 3279 ± 158 b | 3193 ± 197 b |
| RV preload recruitable stroke work (mm Hg) | 20.5 ± 0.9 | 31.2 ± 1.9 b | 25.4 ± 1.3 | 15.1 ± 2.0 | 27.1 ± 2.4 b | 28.5 ± 2.0 b |
| RV chamber compliance (μl/mm Hg) | 0.57 ± 0.03 | 0.41 ± 0.03 b | 0.44 ± 0.03 b | 0.46 ± 0.06 | 0.30 ± 0.02 b | 0.30 ± 0.02 b |
| RV dP/dtmin (mm Hg/s) | –2039 ± 100 | –2892 ± 98 b | –2566 ± 67 b | –1636 ± 133 | –2657 ± 111 b | –2554 ± 143 b |
| RV relaxation factor τ (ms) | 6.7 ± 0.4 | 5.2 ± 0.2 | 4.9 ± 0.3 | 10.1 ± 1.4 | 6.3 ± 0.4 b | 5.1 ± 0.3 b |
Note: Values are means ± SE; n = 9 for CTL, n = 13 for HPH, and n = 10 for CP. BW, body weight; RV, right ventricular; LV, left ventricular; S, septum.
a
P < 0.05 versus CTL
b
P < 0.05 versus HPH
c
P < 0.05 versus room air.