Table 2.
Univariate analysis comparing clinical features between SLE patients with low (<2) FCGR3B and ≥2 FCGR3B gene copy number. Figures indicate mean values or number of patients (percentage). P values derive from Mann-Whitney U test and chi-square testing as appropriate.
| FCGR3B < 2 (n = 21) | FCGR3B ≥ 2 (n = 86) |
P value |
|
|---|---|---|---|
| Age (yrs) | 43.3 | 47.9 | 0.3 |
| Female gender (%) | 18 (86) | 77 (90) | 0.47 |
| Disease duration (months) | 162 | 151 | 0.7 |
| Organ damage present (SDI > 0) | 60 | 58 | 0.9 |
| SLEDAI-2K score | 10.4 | 6.1 | 0.03 |
| LN present (%) | 5 (24) | 6 (6.9) | 0.03 |
| Arthritis present (%) | 4 (19) | 9 (11) | 0.3 |
| Active skin lesions present (%) | 2 (10) | 3 (4) | 0.4 |
| Leukocytopenia (<4) | 3 (14) | 18 (21) | 0.3 |
| Anti-dsDNA positive | 8 (38) | 16 (18) | 0.05 |
| Anti-dsDNA titer (n < 55 IU) | 81 | 37 | 0.03 |
| Anti-C1q positive | 6 (29) | 10 (12) | 0.06 |
| Anti-C1q titer (n < 11 IU) | 22 | 5.5 | 0.003 |
| Antiribosomal P positive | 4 (19) | 6 (7) | 0.1 |
| Antiribosomal P titer (n < 8 IU) | 10 | 5 | 0.01 |
| Anti-Ro positive (%) | 43 | 36 | 0.62 |
| Anti-Sm positive (%) | 5 | 6 | 0.9 |
| Low C3 (<81 mg/dL) (%) | 30 | 28 | 0.9 |
SLEDAI-2K: SLE Disease Activity Index-2000 version, SDI: SLICC-ACR Damage Index, LN: lupus nephritis (see methods for definition), and C3: complement factor 3.