Table 1.
Statistical results (R 2 and SSE) and λ s computed by means of different fitting functions, with distinction between DOTATOC and DOTATATE peptides, with and without accumulation behaviour. Concerning λ MNfix, a single value for each peptide was computed, irrespective of the kinetic behaviour. A negative R 2 (obtained in 6 MNfix fits) means that a constant function equal to the mean value of the data would fit better; that is, the fit is of very poor quality.
| Biological constants λ | ||||||
|---|---|---|---|---|---|---|
| Cases with accumulation | Clearance only cases | |||||
| Mean ±1SD · 10−3 | R 2 median | SEE median | Mean ±1SD · 10−3 | R 2 median | SEE median | |
| (range) (h−1) | (range) | (range) | (range) (h−1) | (range) | (range) | |
| DOTATATE | ||||||
| λ MNfix | 8.6 | 0.71 (−1.6–0.99) | 0.89 (0.07–5.30) | 8.6 | 0.81 (0.40–0.99) | 0.58 (0.004–4.04) |
| λ MN | 7 ± 3 (2–13) | 0.82 (0.08–0.98) | 0.59 (0.007–1.83) | 10 ± 4 (5–21) | 0.94 (0.57–0.99) | 0.25 (0.002–1.07) |
| λ 1BI | 207 ± 147 (42–427) | 0.99 (0.75–1) | 0.017 (0.001–0.147) | 47 ± 9 (9–311) | 0.98 (0.75–0.99) | 0.092 (0–1.057) |
| λ 2BI | 11 ± 5 (6–21) | 16 ± 37 (0–162) | ||||
|
| ||||||
| DOTATOC | ||||||
| λ MNfix | 11.04 | −0.71 (−1.47–0.60) | 2.32 (1.05–11.24) | 11.04 | 0.82 (0.36–0.98) | 0.49 (0.05–9.09) |
| λ MN | 4 ± 2 (1–7) | 0.57 (0.01–0.93) | 0.34 (0.13–4.71) | 13 ± 5 (7–24) | 0.97 (0.66–1.00) | 0.17 (0.002–5.26) |
| λ 1BI | 191 ± 114 (28–308) | 1 (0.89–1) | 0.01 (0–0.02) | 143 ± 155 (9–443) | 0.99 (0.80–1) | 0.025 (0–0.364) |
| λ 2BI | 12 ± 5 (6–22) | 10 ± 5 (0–22) | ||||