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Intrathecal injection of NMDA (2 nmol, ■) causes thermal hyperalgesia when compared to vehicle ◊, and this response is blocked by FeTM-4-PyP5+ in a dose-dependent manner (0.5 nmol (▲), 1 nmol (●), and 2 nmol (□), given intrathecally 15 min before NMDA). Intrathecal injection of FeTM-4-PyP5+ alone (◆, 2 nmol) did not exert any effect. Results are expressed as mean ± SEM for 8 rats; † P < 0.001 compared to vehicle and *P < 0.001 compared to NMDA alone.
