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. 2012 Jan 10;1:2. doi: 10.1038/bonekey.2012.3

Figure 1.

Figure 1

Summary of possible pathways for androgens to regulate bone mass in males. Experimental animal studies using mouse models with inactivation of the androgen receptor (AR), estrogen receptor α (ERα), ERβ or the recently suggested ER GPR30 have demonstrated that the AR and ERα, but not ERβ or GPR30, are involved in the regulation of bone mass in males. (Reproduced from Ohlsson and Vandenput22 with permission from the European Society of Endocrinology.)