Table 4.
The diagnostic criteria of the ROC curve for VEGF in combination with HE4 and CA125 in ovarian cancer patients
| Epithelial ovarian cancer | The ROC criteria | VEGF | HE4 | CA125 | VEGF + HE4 | VEGF + CA 125 | HE4 + CA125 | VEGF + HE4+ CA125 |
|---|---|---|---|---|---|---|---|---|
|
I stage |
AUC |
0.7984* |
0.7284* |
0.7652* |
0.8632* |
0.8784* |
0.8327* |
0.8980* |
| SE |
0.0562 |
0.0708 |
0.0416 |
0.0508 |
0.0475 |
0.0538 |
0.0433 |
|
| 95% C.I. |
0.688-0.909 |
0.590-0.867 |
0.691-0.794 |
0.764-0.963 |
0.785-0.971 |
0.727-0.938 |
0.813-0.83 |
|
| |
p AUC = 0.5 |
<0.001 |
0.0013 |
0.0005 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
|
II stage |
AUC |
0.7231* |
0.7646* |
0.8652* |
0.8592* |
0.8587* |
0.9207* |
0.9207* |
| SE |
0.0647 |
0.0562 |
0.0389 |
0.0421 |
0.0510 |
0.0314 |
0.0294 |
|
| 95% C.I. |
0.596-0.850 |
0.654-0.875 |
0.814-0.967 |
0.777-0.942 |
0.759-0.959 |
0.859-0.982 |
0.863-0.978 |
|
| |
p AUC = 0.5 |
0.0006 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
|
III stage |
AUC |
0.9012* |
0.9256* |
0.9112* |
0.9680* |
0.9665* |
0.9763* |
0.9837* |
| SE |
0.0428 |
0.0291 |
0.0428 |
0.0167 |
0.0221 |
0.0302 |
0.0120 |
|
| 95% C.I. |
0.817-0.985 |
0.869-0.983 |
0.827-0.995 |
0.935-1.001 |
0.923-1.010 |
0.902-1.020 |
0.960-1.007 |
|
| |
p AUC = 0.5 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
|
IV stage |
AUC |
0.7168* |
0.9124* |
0.9472* |
0.9240* |
0.9494* |
0.9420* |
0.9600* |
| SE |
0.0722 |
0.0428 |
0.0260 |
0.0382 |
0.0315 |
0.0353 |
0.0281 |
|
| 95% C.I. |
0.575-0.858 |
0.829-0.996 |
0.896-0.998 |
0.849-0.999 |
0.888-1.011 |
0.873-1.011 |
0.905-1.015 |
|
| |
p AUC = 0.5 |
0.0027 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
|
Total group |
AUC |
0.7843* |
0.8321* |
0.9276* |
0.9032* |
0.9127* |
0.9180* |
0.9404* |
| SE |
0.0376 |
0.0321 |
0.0221 |
0.0239 |
0.0250 |
0.0223 |
0.0187 |
|
| 95% C.I. |
0.711-0.858 |
0.769-0.895 |
0.884-0.971 |
0.856-0.950 |
0.864-0.962 |
0.874-0.962 |
0.904-0.977 |
|
| |
p AUC = 0.5 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
|
Serous epithelial |
AUC |
0.7522* |
0.8720* |
0.9047* |
0.9124* |
0.9009* |
0.9391* |
0.9395* |
| SE |
0.0482 |
0.0347 |
0.0301 |
0.0278 |
0.0312 |
0.0233 |
0.0230 |
|
| 95% C.I. |
0.658-0.847 |
0.804-0.964 |
0.846-0.964 |
0.858-0.967 |
0.840-0.962 |
0.893-0.985 |
0.894-0.985 |
|
| |
p AUC = 0.5 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
|
Endome-trioid epithelial |
AUC |
0.8226* |
0.7843* |
0.9128* |
0.8922* |
0.9268* |
0.8926* |
0.9414* |
| SE |
0.0438 |
0.0467 |
0.0305 |
0.0323 |
0.0299 |
0.0330 |
0.0228 |
|
| 95% C.I. |
0.737-0.908 |
0.693-0.876 |
0.853-0.973 |
0.829-0.955 |
0.868-0.985 |
0.828-0.957 |
0.897-0.986 |
|
| p AUC = 0.5 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
C.I. confidence intervals of AUC.
* statistically significant when comparing tested parameters AUC’s with 0.5 AUC’s.