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. Author manuscript; available in PMC: 2013 Jul 9.
Published in final edited form as: Immunogenetics. 2011 Jul 6;63(12):789–807. doi: 10.1007/s00251-011-0541-9

Figure 6. Ultradeep pyrosequencing results across the NL11 and YL8 epitopes in Mamu-A1*007:01-positive animals.

Figure 6

a. Vpr45-55 NL11 and b. Pol782-789 YL8 epitopes. The Vpr epitope has broad and consistent variation at multiple positions within the epitope demonstrating escape in binding anchor positions and TCR-contact residues. The Pol epitope has some variation; however, none of the substitutions has become the dominant circulating species, even after six years of replication. This may indicate that this region is under functional constraints.