Figure 3. High concentrations of resveratrol induce an increase in mitochondrial proteins in C₂C₁₂ myotubes.

(A) Treatment with 50 µM resveratrol (RSV) for 24 h resulted in an increase in mitochondrial proteins in C₂C₁₂ myotubes in which PGC-1α was overexpressed by infection with an adenovirus expressing PGC-1α (AdPGC-1α). Values are means ± SE for 7–8 experiments. (B) Treatment of wild-type C₂C₁₂ myotubes with 20 µM RSV for 6 h, followed by 18 h recovery, for 3 d induced increases in PGC-1α and mitochondrial proteins. Values are means ± SE for 6–8 experiments. *RSV versus control, p<0.05.