Table 3.
Univariate and multivariate analysis for clinicopathologic variables
| |
Univariate analysis |
Multivariate analysis |
||||
|---|---|---|---|---|---|---|
| Parameters | HRa | 95% CIb | Pc | HRa | 95% CIb | Pc |
| Gender |
|
|
|
|
|
|
| Male vs. female |
1.032 |
0.782-1.363 |
0.826 |
|
|
|
| Age (years) |
|
|
|
|
|
|
| <52 vs.≥52 |
0.995 |
0.756-1.311 |
0.948 |
|
|
|
| Histologic subtype |
|
|
|
|
|
|
| ad vs l |
1.111 |
0.842-1.466 |
0.456 |
|
|
|
| T classification |
|
|
|
|
|
|
| T1–T2 vs. T3–T4 |
0.956 |
0.832-1.099 |
0.529 |
|
|
|
|
C classification |
|
|
|
|
|
|
|
I-II vs. III |
0.961 |
0.818-1.129 |
0.629 |
|
|
|
| Differention |
|
|
|
|
|
|
| Grade1,Grade2,Grade3 |
1.520 |
1.272-1.816 |
0.000 |
1.526 |
1.273-1.829 |
0.000 |
| Membranous |
|
|
|
|
|
|
| positive and negative |
0.763 |
0.571-1.021 |
0.069 |
0.820 |
0.609-1.106 |
0.193 |
| Cytoplasmic |
|
|
|
|
|
|
| positive and negative |
1.815 |
1.375-2.396 |
0.000 |
1.871 |
1.412-2.478 |
0.000 |
| Nuclear |
|
|
|
|
|
|
| positive and negative |
3.864 |
2.872-5.200 |
0.000 |
3.776 |
2.786-5.118 |
0.000 |
| Nanog |
|
|
|
|
|
|
| positive and negative | 1.994 | 1.494-2.661 | 0.000 | 1.700 | 1.249-2.315 | 0.001 |
a HR Harzard Rate.
b CI Confidence Interval.
c Cox regression model.
The expression levels of cytoplasmic and nuclear β-catenin and Nanog were an independent prognosticator for overall survive.