Table 1.
Distribution of secretoglobin mRNA expression in normal ovaries (NO) and epithelial ovarian cancers (EOC) and correlation with MGB2 gene expression*
| Secretoglobin | % expressing |
Relative mRNA expression |
p value | Correlation with SCGB2A1 gene expression | |
|---|---|---|---|---|---|
|
Mean (SD) | |||||
| Rho cc | p value | ||||
| SCGB2A1 (Mammaglobin B) |
EOC 46/53 = 86.7% |
186883.54 (63045.00) |
p < 0.001 |
1 |
- |
| NO 2/23 = 8.6% |
1432.00 (648.59) |
||||
| SCGB2A2 (Mammaglobin A) |
EOC 36/53 = 67.9% |
23295.42 (21171.01) |
p < 0.001 |
0.63 |
p < 0.001 |
| NO 2/30 = 6.6% |
0.37 (0.33) |
||||
| SCGB1D1 (Lipophilin A) |
EOC 40/53 = 75.4% |
4741.58 (2680.96) |
p < 0.001 |
0.66 |
p < 0.001 |
| NO 2/30 = 6.6% |
5.83 (4.19) |
||||
| SCGB1D2 (Lipophilin B) |
EOC 40/53 = 75.4% |
122631.77 (48990.82) |
p < 0.001 |
0.77 |
p < 0.001 |
| NO 5/30 = 16.6% |
3818.80 (1908.12) |
||||
| SCGB3A1 (HIN-1) |
EOC 8/53 = 15.1% |
386,48 (1606,95) |
p = 0.21 |
0.39 |
p < 0.001 |
| NO 3/30 = 10.0% |
2194.48 (6305.41) |
||||
| SCGB1C1 (RYD5) |
EOC 37/53 = 69.8% |
57.79(26.83) |
p < 0.001 |
0.36 |
p < 0.001 |
| NO 3/30 = 10% |
2.70 (2.14) |
||||
| SCGB1D4 (IIS) |
EOC 29/53 = 54.7% |
72084.23 (69346.5) |
p = 0.411 |
0.50 |
p < 0.001 |
| NO 10/26 = 38.4% |
340.77 (158.75) |
||||
| SCGB1A1 (Uteroglobin) |
EOC 11/53 = 20.7% |
138.72 (117.09) |
p = 0.452 |
0.25 |
p = 0.03 |
| NO 5/30 = 16.6% |
185.43 (116.76) |
||||
| SCGB3A2 (UGRP-1) | EOC 6/53 = 11.3% |
2.85 (1.65) |
p = 0.190 | 0.16 | p = 0.17 |
| NO 1/30 = 3.3% | 0.17 (0.16) | ||||
* The p value indicates significance in the difference between NO and EOC for each secretoglobin mRNA expression (ns = not significant, SD = standard deviation, Rho cc = Spearman Rho correlation coefficient).