Table 4.
Univariate and multivariate analyses of overall survival (OS), disease-free survival (DFS) and progression-free survival (PFS) in relation to clinical parameters
|
Univariate survival analysis | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |
OS |
DFS |
PFS |
|||||||||
| Variables | N | HR | 95% CI | p | N | HR | 95% CI | p | N | HR | 95% CI | p |
|
LipB mRNA RQ |
|
|
|
|
|
|
|
|
|
|
|
|
| Low vs high tertile |
92 |
1.6 |
0.7-3.3 |
0.220 |
64 |
2.5 |
1.1-5.6 |
0.020 |
88 |
2.2 |
1.1-4.3 |
0.030 |
|
LipB IHC |
|
|
|
|
|
|
|
|
|
|
|
|
| Continuous |
92 |
1.4 |
0.6-3.3 |
0.400 |
67 |
0.99 |
0.3-2.4 |
0.980 |
91 |
1.3 |
0.6-2.8 |
0.499 |
|
LipB IHC |
|
|
|
|
|
|
|
|
|
|
|
|
| Categoric |
|
|
|
|
|
|
|
|
|
|
|
|
| IHC = 2 vs IHC ≤ 1 |
92 |
0.8 |
0.4-1.6 |
0.604 |
67 |
0.81 |
0.4-1.6 |
0.552 |
91 |
0.9 |
0.5-1.7 |
0.892 |
| IHC = 3 vs IHC ≤ 1 |
|
1.7 |
0.7-3.7 |
0.183 |
|
1.15 |
0.4-2.9 |
0.764 |
|
1.4 |
0.6-3.1 |
0.353 |
|
Age (years) |
|
|
|
|
|
|
|
|
|
|
|
|
| >60 vs ≤60 |
92 |
2.0 |
1.1-3.7 |
0.017 |
67 |
1.15 |
0.6-2.1 |
0.660 |
91 |
1.85 |
1.1-3.2 |
0.026 |
|
FIGO stage |
|
|
|
|
|
|
|
|
|
|
|
|
| III-IV vs I-II |
92 |
8.1 |
2.5-26.2 |
<0.01 |
67 |
6.6 |
2.5-17.1 |
<0.01 |
91 |
7.8 |
2.8-21.7 |
<0.01 |
|
Residual tumor (cm) |
|
|
|
|
|
|
|
|
|
|
|
|
| RT > 0 vs RT = 0 |
92 |
3.7 |
1.8-7.8 |
<0.01 |
67 |
2.4 |
1.2-4.6 |
0.010 |
91 |
3.4 |
1.7-6.5 |
<0.01 |
|
Presence of ascites |
|
|
|
|
|
|
|
|
|
|
|
|
| Yes vs no |
92 |
2.6 |
1.4-5.1 |
0.003 |
67 |
2.8 |
1.4-5.4 |
0.002 |
91 |
2.6 |
1.4-4.7 |
<0.01 |
|
Lymph node involvement |
|
|
|
|
|
|
|
|
|
|
|
|
| Positive vs negative |
73 |
1.9 |
0.9-4.0 |
0.04 |
58 |
3.4 |
1.7-6.7 |
0.001 |
73 |
2.8 |
1.4-5.2 |
0.002 |
|
Multivariate survival analysis | ||||||||||||
|
Variables |
OS |
DFS |
PFS |
|||||||||
|
N |
HR |
95% CI |
p |
N |
HR |
95% CI |
p |
N |
HR |
95% CI |
p |
|
|
LipB mRNA RQ |
|
|
|
|
|
|
|
|
|
|
|
|
| Low vs high tertile |
92 |
1.8 |
0.9-3.9 |
0.103 |
64 |
3.9 |
1.7-9.1 |
0.001 |
88 |
2.8 |
1.4-5.8 |
0.004 |
|
FIGO stage |
|
|
|
|
|
|
|
|
|
|
|
|
| III-IV vs I-II |
92 |
5.1 |
1.2-20.5 |
0.022 |
67 |
13.7 |
4.3-43.2 |
<0.01 |
91 |
5.8 |
1.7-19.4 |
0.004 |
|
Residual tumor (cm) |
|
|
|
|
|
|
|
|
|
|
|
|
| RT > 0 vs RT = 0 |
92 |
1.1 |
0.4-2.9 |
0.799 |
67 |
4.9 |
0.07-0.57 |
0.003 |
91 |
1.02 |
0.4-2.3 |
0.964 |
|
Presence of ascites |
|
|
|
|
|
|
|
|
|
|
|
|
| Yes vs no | 92 | 1.6 | 0.8-3.4 | 0.180 | 67 | 3.3 | 1.3-8.3 | 0.009 | 91 | 1.8 | 0.9-3.6 | 0.095 |