Figure 5. Down-regulation of proteins associated with proliferation, anti-apoptosis and invasion in tumor after the combination therapy.

(A) Western blot analysis showed that VEGF-Trap combined with gemcitabine inhibited the expression of Cyclin D1, Pro-Caspase-3, Bcl-2, MMP2 and MMP9 in LLC tumors; (B) Quantitation of protein levels. β-actin served as an internal control. Densitometer quantitation was relative to the first data set in each case (indicated by a value of 1). All data are representative of at least two independent experiments. *P<0.05, **P<0.01 vs the control group.