Figure 2. Effects of treatment with mDEF201 on survival from a vaccinia virus systemic infection (initiated by a 100-µl i.p. virus inoculation) in mice.

Intranasal 5- and 50-µl treatments with mDEF201 (PFU/mouse) were given one time only 24 hours prior to virus exposure. There were 10 treated animals per group and 20 placebos per group at the start of the experiment. ***P<0.001, compared to placebo.