Figure 5. Effects of extended prophylaxis with different doses of mDEF201 on survival (A) and body weight change (B) during a vaccinia virus lower respiratory infection (initiated by a 50-µl i.n. virus inoculation) in mice.

Single 50-µl i.n. treatments (PFU/mouse) were given on the day indicated prior to virus challenge. Figure 5B shows mean values ± SEM. There were 10 treated animals per group, 20 placebos, and 6 normal control mice (uninfected, untreated) at the start of the experiment. ***P<0.001, compared to placebo.