Table 2. Lipids, lipoproteins and metabolic markers according to LIPC genotypes and case-control design.
Cases | Controls | |||||||
p value forcase-controleffect | p value forLIPCeffect | |||||||
CC | CT | TT | CC | CT | TT | |||
Numbers of subjects | 322 | 196 | 39 | 356 | 192 | 12 | ||
TC (g/L) | 1.99 (0.43) | 2.05 (0.38) | 2.08 (0.52) | 2.22 (0.35) | 2.29 (0.41) | 2.35 (0.51) | 0.001 | 0.03 |
HDLc (g/L) | 0.43 (0.12) | 0.43 (0.14) | 0.44 (0.10) | 0.55 (0.12) | 0.56 (0.14) | 0.62 (0.12) | 0.001 | 0.31 |
LDLc (g/L) | 1.25 (0.37) | 1.27 (0.34) | 1.31 (0.48) | 1.45 (0.32) | 1.47 (0.35) | 1.49 (0.42) | 0.001 | 0.40 |
TG (g/L)* | 1.62 (0.96) | 1.77 (0.91) | 1.73 (0.91) | 1.13 (0.61) | 1.30 (1.02) | 1.33 (0.74) | 0.001 | 0.02 |
Apo A-1 (g/L) | 1.22 (0.21) | 1.23 (0.25) | 1.27 (0.18) | 1.51 (0.23) | 1.52 (0.25) | 1.68 (0.21) | 0.001 | 0.07 |
Apo B (g/L) | 1.04 (0.23) | 1.07 (0.22) | 1.10 (0.32) | 1.09 (0.21) | 1.13 (0.22) | 1.13 (0.28) | 0.001 | 0.04 |
Apo E (g/L)* | 99.6 (59.3) | 108.5 (61.4) | 100.7 (71.9) | 72.3 (42.3) | 79.7 (55.2) | 67.1 (43.8) | 0.001 | 0.12 |
Apo C3 (g/L)* | 32.3 (12.5) | 34.3 (12.8) | 39.6 (23.5) | 30.2 (11.9) | 31.5 (14.7) | 35.8 (16.8) | 0.001 | 0.009 |
Glycaemia (g/L)* | 1.11 (0.41) | 1.06 (0.35) | 1.10 (0.45) | 0.97 (0.17) | 0.99 (0.20) | 1.00 (0.19) | 0.001 | 0.86 |
Insulin (IU/L)* | 16.1 (21.3) | 14.9 (23.6) | 23.1 (38.5) | 9.5 (6.8) | 10.5 (7.8) | 10.8 (6.9) | 0.001 | 0.37 |
HOMA-IR* | 4.9 (11.8) | 4.1 (6.5) | 6.5 (10.9) | 2.4 (2.1) | 2.7 (2.7) | 2.8 (2.3) | 0.001 | 0.45 |
Adiponectin (mg/L) | 5.8 (4.2) | 6.0 (5.1) | 6.0 (4.6) | 7.2 (4.9) | 6.6 (3.9) | 4.8 (3.3) | 0.001 | 0.62 |
Metabolic syndrome (NCEP-ATPIII) | 52.8% | 46.9% | 48.7% | 16.3% | 17.7% | 16.6% | 0.001 | 0.72 |
Analyses were performed on log transformed data.