Table 3.

Amphetamine-induced change in [¹¹C]FLB 457 BP_ND and dialysate DA in frontal cortex

Amphetamine Dose	Animal	PET Baseline BPND	AMPH BPND	Δ BPND	Microdialysis Baseline DA* (nM)	Δ Peak DA (%)	Δ Average DA (%)
0.3 mg/kg	A	0.85	0.73	−14%	0.53	837	671
PET: n=7experiments/4 animals	C	0.96	0.91	−5%	-	-	-
MD: n=4 experiments/4 animals	C	0.97	0.86	−11%	0.27	1100	924
	D	0.89	0.89	+1%	0.47	707	522
	D	0.65	0.60	−7%	-	-	-
	E	0.81	0.82	+2%	-	-	-
	E	0.97	0.91	−6%	-	-	-
	E	-	-	-	0.39	1352	941
Mean +/− SD		0.87 ± 0.12	0.82 ± 0.11	−5.9% ± 5.5%	0.42 ± 0.11	999 ± 286	765 ± 203
0.5 mg/kg	A	0.97	0.81	−17%	0.51	1239	871
PET: n=9 experiments/5 animals	A	0.78	0.64	−18%	0.23	1500	1178
MD: n=9 experiments /4 animals	B	0.83	0.69	−17%	-	-	-
	C	1.03	0.86	−16%	0.28	1048	745
	C	0.96	0.79	−19%	0.07	1110	856
	D	0.82	0.73	−11%	0.21	1249	996
	D	0.77	0.63	−18%	0.17	2123	1777
	E	1.01	0.94	−7%	0.26	1470	1254
	E	1.17	0.99	−16%	-	-	-
	E	-	-	-	0.20	1589	917
	E	-	-	-	0.45	550	441
Mean +/− SD		0.93 ± 0.13	0.79 ± 0.13	−15.5% ± 3.8%	0.27 ± 0.14	1320 ± 432	1004 ± 375
1 mg/kg	A	0.87	0.68	−22%	0.23	1365	1027
PET: n=4 experiments/3 animals	A	0.87	0.67	−24%	0.11	3670	2996
MD: n=5 experiments /3 animals	A	-	-	-	0.20	3200	2602
	B	0.88	0.66	−24%	0.23	1543	1241
	D	0.81	0.60	−26%	0.38	1997	1608
Mean +/− SD		0.86 ± 0.03	0.65 ± 0.04	− 23.9% ± 1.7%	0.23 ± 0.10	2355 ± 1026	1895 ± 863

MD- Microdialysis; AMPH- Amphetamine; SD-Standard Deviation

^*Mean values of n=3 to 4 baseline dopamine samples from −30 to 0 minutes before amphetamine