Table 2.

Summary of GWAS and replication analyses in all asthma clinical trials.

							Replication #1	Replication #2
SNP	Chr	MA	MAF	Gene	Model	CAMP GWAS (effect estimate)	Pooled AT/LOCCS/LODO	ACRN	CARE	GACRS	Liptak Combined P val
rs11252394	10	A	0.08		Additive	0.0099b (+)	1.21E-06	0.4173	0.3472	-	1.98E-07
rs6988229	8	T	0.20	COL22A1	Recessive	0.0004c (+)	0.0050	0.0505	0.9283	0.0139	8.51E-06
rs9552679	13	C	0.26		Additive	0.0007d (−)	0.0004	0.7884	0.4410	-	3.02E-05
rs1663330	14	G	0.33		Additive	0.0020b (+)	0.0028	0.0234	0.7544	-	4.54E-05
rs1663332	14	T	0.37		Additive	0.0028b(+)	0.0006	0.0374	0.6874	0.3595	8.07E-05
rs17495520	5	T	0.14		Additive	0.038b (+)	0.0110	0.0030	0.3587	-	0.0003
rs10511905	9	G	0.22		Additive	0.006a (−)	0.0087	0.1388	0.3149	-	0.0003
rs518350	22	T	0.12		Recessive	0.0065e (+)	0.0010	0.4987	0.2090	0.3334	2.70E-04
rs17701271	4	A	0.22		Recessive	0.004c (+)	0.0026	0.1371	0.8756	0.2031	0.0003
rs6002674	22	C	0.15		Recessive	0.0012e (−)	0.0040	0.9808	0.0310	0.5675	0.0027
rs1419555	7	T	0.37		Additive	0.0043d (+)	0.0060	0.7723	0.6879	0.4932	0.0068
rs1423515	5	A	0.05		Additive	0.027b (+)	0.0400	0.4104	0.4710	-	0.0089
rs1522113	4	A	0.05	CLOCK	Additive	0.014b (+)	0.0037	0.9260	0.0427	0.8633	0.0177

Association results for 13 replicated SNPs (p-values < 0.05) from the primary replication phase only are shown, sorted by Liptak Combined P-values. The p-values presented for CAMP are 2-sided while p-values for the replication populations are 1-sided, based on the direction of association (denoted as + or −) relative to the CAMP analysis. MAF: minor allele frequency in CAMP.

^aLowest p-value is with the family-based association test (FBAT)

^bLowest p-value is with the additive generalized linear model

^cLowest p-value is with the recessive generalized linear model

^dLowest p-value is with the additive longitudinal analysis

^eLowest p-value is with the recessive longitudinal analysis