Table 1.
Gene ontology (GO) enrichment analysis of 719 aging-associated genes in retinal microglia
| Cellular Process | Enrichment Score1 | ||
|---|---|---|---|
| Metabolic process | lipid biosynthetic process | triglyceride metabolic process | 8.21 |
| very long-chain fatty acid biosynthetic process | 7.17 | ||
| platelet activating factor biosynthetic process | 6.01 | ||
| steroid biosynthetic process | 5.13 | ||
| isocitrate metabolic process | 4.46 | ||
| fatty acid metabolic process | 4.34 | ||
| Biological Regulation | positive regulation of transcription, DNA- dependent | positive regulation of transcription from RNA polymerase II promoter | 7.64 |
| negative regulation of DNA binding | 7.34 | ||
| regulation of transcription, DNA-dependent | 5.58 | ||
| regulation of transcription from RNA polymerase II promoter | 3.22 | ||
| regulation of signal transduction | negative regulation of ERK1 and ERK2 cascade | 6.71 | |
| negative regulation of Rho protein signal transduction | 6.34 | ||
| positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway | 4.46 | ||
| positive regulation of I-kappaB kinase/NF-kappaB cascade | 3.7 | ||
| positive regulation of MAPKKK cascade | 3.46 | ||
| Regulation of activity | inactivation of MAPK activity | 6.48 | |
| positive regulation of metalloenzyme activity | 6.01 | ||
| positive regulation of protein serine/threonine kinase activity | 4.78 | ||
| positive regulation of NF-kappaB transcription factor activity | 3.23 | ||
| regulation of phosphorylation | positive regulation of peptidyl-serine phosphorylation | 6.96 | |
| negative regulation of peptidyl-serine phosphorylation | 3.44 | ||
| regulation of homeostatic process | positive regulation of release of sequestered calcium ion into cytosol | 9.97 | |
| negative regulation of cellular process | negative regulation of cell proliferation | 6.06 | |
| negative regulation of cell growth | 5.75 | ||
| regulation of localization | positive regulation of potassium ion transport | 6.72 | |
| regulation of cellular component organization | positive regulation of endocytosis | 5.44 | |
| positive regulation of protein complex assembly | 3.44 | ||
| Transport | organic substance transport | L-glutamate import | 7.71 |
| D-aspartate import | 6.01 | ||
| L-glutamate transport | 5.7 | ||
| L-amino acid transport | 4.26 | ||
| dicarboxylic acid transport | 4.14 | ||
| intracellular protein transport | protein targeting | 4.94 | |
| protein import into nucleus, translocation | 4.26 | ||
| secretion by cell | calcium ion-dependent exocytosis | 5.44 | |
| exocytosis | 3.17 | ||
| Immune system process | microglial cell activation | 5.34 | |
| Locomotion | cell migration | 6.01 | |
| Cellular component organization or biogenesis | histone ubiquitination | 6.72 |
1
Log transformation of the p-value calculated usinga chi-square test comparing the proportion of genes in the list showing differential expression in a given GO group to the proportion of all genes in the same GO group.