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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Neurobiol Aging. 2013 Apr 19;34(10):2310–2321. doi: 10.1016/j.neurobiolaging.2013.03.022

Table 2.

Canonical pathway analysis of 719 genes differentially expressed with aging in retinal microglia.

Canonical Pathways Age-related genes Ratio1 P-value
Pathways related to microglial immune function and regulation
IL-17A Signaling FOS, JUN, MAPK10, TNF 0.1600 0.010000
Ceramide Signaling S1PR4, FOS, JUN, S1PR5, PIK3C2A, TNFRSF1A, PPM1L, PIK3R6, MRAS, PPP2R5E, TNF 0.1260 0.000071
IL-3 Signaling FOS, PRKCI, J UN, PIK3C2A, CHP, PIK3R6, MRAS, PRKCE 0.1080 0.002951
IL-1 Signaling GNB1, FOS, JUN, PRKAR2B, MYD88, GNAO1, MRAS, MAPK10, PRKAR2A, GNG3, ADCY7 0.1040 0.000288
Nitric Oxide Signaling VEGFA, BDKRB2, PRKAR2B, GUCY1A3, PIK3C2A, KDR, PIK3R6, CAV1, PRKAR2A, SLC7A1 0.1000 0.000372
Estrogen-Dependent Breast Cancer Signaling FOS, JUN, PIK3C2A, PIK3R6, MRAS, HSD17B12, HSD17B1 0.1000 0.004365
LPS-stimulated MAPK Signaling FOS, PRKCI, JUN, PIK3C2A, PIK3R6, MRAS, MAPK10, PRKCE 0.0976 0.003548
Pathways related to angiogenesis
Inhibition of Angiogenesis by TSP1 VEGFA, JUN, GUCY1A3, KDR, MAPK10, CD36 0.1540 0.000955
VEGF Family Ligand-Receptor Interactions VEGFA, FOS, PRKCI, PIK3C2A, KDR, PLA2G5, PIK3R6, MRAS, PRKCE 0.1070 0.001175
Pathways related to trophic factors
Neurotrophin/TRK Signaling FOS, JUN, Klk1b1, PIK3C2A, SPRY2, PIK3R6, MRAS, SORCS1 0.1100 0.001698
1

Number of genes in the list of age-related genes in a given canonical pathway divided by the total number of genes mapping to that pathway.