Table 5. Metabolites that contribute to the separation of male from female for wild-type control (a) and IL-10 gene-deficient mice (b).
| Metabolites thatcontribute toseparation of males onthe PLS-DA plot | Age (Weeks) | Metabolites thatcontribute to separationof females on the PLS-DAplot | Age (Weeks) | ||||||||||
| 4 | 6 | 8 | 12 | 16 | 20 | 4 | 6 | 8 | 12 | 16 | 20 | ||
| Metabolites Common to Wild-Type (a) And IL-10 Gene-Deficient (b) Mice | |||||||||||||
| Succinate | ab | ab | ab | ab | ab | ab | 1-Methylnicotinamide | ab | ab | ab | ab | ab | ab |
| Taurine | ab | ab | ab | ab | ab | Lactate | b | ab | ab | ab | ab | ab | |
| Valine | ab | ab | ab | ab | ab | Trimethylamine N-oxide | b | ab | ab | ab | b | ab | |
| Trimethylamine | a | ab | ab | ab | ab | ab | Pyruvate | b | ab | ab | b | ab | ab |
| Methylamine | a | ab | ab | ab | ab | ab | Glutarate | ab | ab | ab | ab | B | |
| N-Isovaleroylglycine | a | ab | ab | ab | ab | ab | N-Carbomoyl-β-alanine | ab | ab | a | ab | ||
| Ethanolamine | ab | ab | a | a | 3-Methyl-2-Oxovalerate | a | a | a | ab | a | a | ||
| Butyrate | a | ab | ab | b | a | Glycolate | a | a | ab | a | |||
| Creatine | ab | ab | b | b | cis-Aconitate | b | b | b | a | ab | |||
| Isoleucine | a | ab | a | b | b | ||||||||
| Adipate | a | a | a | ab | |||||||||
| Pyroglutamate | b | b | ab | ||||||||||
| 3-Hydroxybutyrate | ab | ||||||||||||
| Metabolites Common But At Different Time Points In Wild-Type (a) And IL-10 Gene-Deficient (b) Mice | |||||||||||||
| N,N-Dimethylglycine | a | a | a | b | Fucose | b | a | a | a | ||||
| Uracil | a | b | Betaine | b | a | ||||||||
| 2-Aminobutyrate | b | b | a | ||||||||||
| Metabolites Unique To Wild-Type (a) Mice | |||||||||||||
| Trigonelline | a | Guanidoacetate | a | a | |||||||||
| Dimethylamine | a | Formate | a | a | a | a | |||||||
| 2-Hydroxyisobutyrate | a | a | a | Glycin | a | a | |||||||
| citrate | a | a | 2-Oxoisocaproate | a | a | a | a | ||||||
| trans-Aconitate | a | Acetate | a | a | |||||||||
| Methanol | a | Allantoin | a | a | |||||||||
| Hippurate | a | Mannose | a | a | |||||||||
| Phenylacetylglycine | a | ||||||||||||
| 3-Indoxysulfate | a | ||||||||||||
| Metabolites Unique To IL-10 Gene-Deficient (b) Mice | |||||||||||||
| Tyrosine | b | Urea | b | ||||||||||
| Xylose | b | O-Acetylcarnitine | b | ||||||||||
| Asparagine | b | b | b | b | Taurine | b | |||||||
| 2-Oxoisocaproate | b | Isoleucine | b | ||||||||||
| Betaine | b | Adipate | b | ||||||||||
| Malonate | b | b | b | Carnitine | b | ||||||||
| Carnitine | b | Hippurate | b | b | |||||||||
| Glucose | b | Xylose | b | ||||||||||
| Mannose | b | ||||||||||||
| Total Common | 2 | 9 | 8 | 10 | 6 | 6 | Total Common | 1 | 5 | 6 | 6 | 5 | 6 |
| Total Wild-Type | 11 | 4 | 4 | 4 | 1 | 3 | Total Wild-Type | 4 | 3 | 4 | 3 | 11 | 9 |
| Total IL-10 Gene-Deficient | 3 | 4 | 2 | 3 | 6 | 7 | Total IL-10 Gene-Deficient | 12 | 2 | 2 | 1 | 2 | 1 |