Table 3.
Summary of Nanog regulators
| Factor | Mode of regulation | Effect on Nanog | References |
|---|---|---|---|
| Nanog | Transcriptional & epigenetic | Activator & repressor | [41,62,80,81, 83] |
| Zfp281 | Transcriptional & epigenetic | Repressor | [41,81] |
| Zfp143 | Transcriptional | Activator | [59] |
| Oct4 | Transcriptional & epigenetic | Activator | [51,52,56,59, 62, 73, 77, 80] |
| Sox2 | Transcriptional & epigenetic | Activator | [51,52,62,73, 75] |
| Klf4 | Transcriptional | Activator | [20,60,61,62] |
| Tcf3 | Transcriptional | Activator & repressor | [53, 63, 73] |
| Esrrb | Transcriptional | Activator | [54, 55, 56, 57, 58, 73] |
| Ncoa3 | Transcriptional | Activator | [57, 58] |
| Zic3 | Transcriptional | Activator | [82] |
| Cdx2 | Transcriptional | Repressor | [64] |
| Gcnf | Transcriptional | Repressor | [65] |
| Sp1 | Transcriptional | Activator | [66] |
| Sp3 | Transcriptional | Activator | [66] |
| Timp2 | Transcriptional (Nanog promoter-driven luciferase assay) | Activator | [67] |
| Hig2 | Transcriptional (Nanog promoter-driven luciferase assay) | Activator | [67] |
| Mki67ip | Transcriptional (Nanog promoter-driven luciferase assay) | Activator | [67] |
| Esrrg | Transcriptional (Nanog promoter-driven luciferase assay) | Activator | [67] |
| Dusp7 | Transcriptional (Nanog promoter-driven luciferase assay) | Activator | [67] |
| Spi1 | Transcriptional (Nanog promoter-driven luciferase assay) | Repressor | [67] |
| Prkaca | Transcriptional (Nanog promoter-driven luciferase assay) | Repressor | [67] |
| Jun | Transcriptional (Nanog promoter-driven luciferase assay) | Repressor | [67] |
| Tbx3 | Transcriptional | Activator | [20] |
| Stat3 | Transcriptional | Activator | [68, 73] |
| Brachyury | Transcriptional | Activator | [68] |
| PBAF complex | Transcriptional & epigenetic | Repressor | [73] |
| p53 | Transcriptional | Repressor | [74] |
| Sin3a/HDAC complex | Transcriptional & epigenetic | Activator & repressor | [74, 75] |
| Mof | Epigenetic | Activator | [76] |
| Wdr5 | Transcriptional & epigenetic | Activator | [77] |
| Ezh2 | Epigenetic | Repressor | [78] |
| Satbl | Transcriptional & epigenetic | Repressor | [79] |
| Satb2 | Transcriptional & epigenetic | Activator | [79] |
| NuRD/NODE complexes | Transcriptional & epigenetic | Repressor | [80, 81] |