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. 2013 Jul 9;8(7):e66518. doi: 10.1371/journal.pone.0066518

Figure 1. Effects of IS on SLCO4C1 expression.

Figure 1

(A) The mRNA expression levels of human SLCO4C1 24 h after treatment with various uremic solutes in ACHN are shown. IS, indoxyl sulfate; SDMA, symmetric demethylarginine; ADMA, asymmetric dimethylarginine; GSA, guanidinosuccinate; t-Aco, trans-aconintate; c-Aco, cis-aconitate; TMAO, trimethylamine N-oxide; IAA, indole-3-acetate. All the concentrations were 1.0 mM. (B) Effect of IS on SLCO4C1 mRNA expression in HK-2 cells. HK-2 cells were incubated with IS for 24 h. **P<0.01 versus control (n = 3–4 per group).