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. Author manuscript; available in PMC: 2014 Mar 13.

Published in final edited form as: Biochemistry. 2013 Feb 27;52(10):10.1021/bi400037w. doi: 10.1021/bi400037w

Table 1.

Product inhibition patterns for Mtb ICDH-1

Experiment	Pattern	Fitted Parameters
NADPH vs. NADP⁺	C	appK_is = 6 ± 2 μM
NADPH vs. isocitrate	NC	appK_is = 10 ± 2 μM appK_ii = 49 ± 8 μM
αKG vs. NADP⁺	NC	appK_is = 22 ± 6 mM appK_ii = 11 ± 1 mM
malate vs. NADP⁺	NC	appK_is = 80 ± 15 mM appK_ii = 198 ± 19 mM
malate vs. isocitrate	NC	appK_is = 98 ± 15 mM appK_ii = 516 ± 114 mM

C, competitive; NC, noncompetitive