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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Exp Neurol. 2013 Jan 16;247:392–401. doi: 10.1016/j.expneurol.2013.01.005

Figure 2. Activation of the PGC-1α-mediated endurance pathway in skeletal muscle (whole cell lysate) during hibernation.

Figure 2

A, Real-time PCR of PGC-1α in whole muscle lysate reveals significantly enhanced mRNA levels during hibernation. B, Western blot and density analyses of PGC-1α and its down- and upstream targets: protein levels of p-AMPK, p-38, Nuclear Respiratory Factors 1 and 2 (Nrf-1 and Nrf-2), and GLUT4 are significantly upregulated in hibernating quadriceps muscle. (*P<0.05; **P<0.01; ***P<0.001)