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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Neurobiol Aging. 2013 Apr 30;34(10):2421–2430. doi: 10.1016/j.neurobiolaging.2013.04.002

Fig. 4. The administration of tolfenamic acid to hemizygous APP YAC R1.40 mice improves spatial memory.

Fig. 4

Tolfenamic acid was administered by oral gavage daily for 34 days. See the methods section for details. A) Acquisition patterns during daily training trials of 5 mg/kg/day, 50 mg/kg/day and vehicle groups; B) Probe trials assessing the long-term memory retention on Days 1 and 11 following acquisition training trials. “*” Indicates that values are significantly different from vehicle, as determined by one-way ANOVA analysis with Tukey-Kramer post-hoc test to compare all pairs of columns (p<0.05), obtained using GraphPad InStat 3 software. Vehicle n=6; 5 mg/kg/day n=6; 50 mg/kg/day n=7.