Fig. 5. Working memory improvement in hemizygous APP YAC transgenic mice, line R1.40, after administration of tolfenamic acid assessed by spontaneous alternations in the Y-maze.
Tolfenamic acid was administered by oral gavage daily for 34 days. See the methods section for details. “*” Indicates that values are significantly different from vehicle control, as determined by one-way ANOVA analysis with Tukey-Kramer post-hoc test to compare all pairs of columns (p<0.05), obtained using GraphPad InStat 3 software. Vehicle n=6; 5 mg/kg/day n=6; 50 mg/kg/day n=7.