Table 2. Effects of ZNRD1and RNF39 gene SNPs on AIDS progression of HIV-1 patients in a Han Chinese population in Taiwan.
| Gene | Location | Position | SNP | Genotype | Patients with AIDS progression | Patients with AIDS-non progression | p-value | HR | 95% CI | |
| Genotype frequency (no (%)) | Genotype frequency (no (%)) | |||||||||
| ZNRD1 | 5′ near gene | 30,028,352 | SNP1 | rs3757328 | GG | 59 (67.8) | 43 (82.7) | 0.325 | 0.797 | 0.508–1.251 |
| AG+AA | 28 (32.2) | 9 (17.3) | ||||||||
| 5′ near gene | 30,028,424 | SNP2 | rs3757329 | AA | 56 (64.4) | 38 (73.1) | 0.937 | 0.982 | 0.633–1.526 | |
| AC+CC | 31 (35.6) | 14 (26.9) | ||||||||
| 5′ near gene | 30,028,807 | SNP3 | rs7769930 | AA | 56 (64.4) | 38 (73.1) | 0.937 | 0.982 | 0.633–1.526 | |
| AC+CC | 31 (35.6) | 14 (26.9) | ||||||||
| intron | 30,030,189 | SNP4 | rs9261271 | TT | 82 (94.3) | 46 (88.5) | 0.161 | 1.909 | 0.772–4.720 | |
| AT+AA | 5 (5.7) | 6 (11.5) | ||||||||
| intron | 30,030,689 | SNP5 | rs1150740 | CC | 85 (97.7) | 49 (94.2) | 0.328 | 2.014 | 0.495–8.195 | |
| AC+AA | 2 (2.3) | 3 (5.8) | ||||||||
| intron | 30,031,345 | SNP6 | rs1150739 | AA | 29 (34.1) | 19 (36.5) | 0.398 | 1.215 | 0.773–1.910 | |
| AG+GG | 56 (65.9) | 33 (63.5) | ||||||||
| intron | 30,032,319 | SNP7 | rs11752321 | CC | 61 (70.1) | 44 (84.6) | 0.361 | 0.807 | 0.509–1.279 | |
| CG+GG | 26 (29.9) | 8 (15.4) | ||||||||
| 3′ near gene | 30,032,917 | SNP8 | rs16896970 | AA | 47 (54.0) | 38 (73.1) | 0.006 | 0.551 | 0.359–0.845 | |
| AG+GG | 40 (46.0) | 14 (26.9) | ||||||||
| RNF39 | 3′ near gene | 30,037,686 | SNP1 | rs8347 | GG | 33 (40.7) | 17 (35.4) | 0.682 | 0.911 | 0.584–1.422 |
| AG+AA | 48 (59.3) | 31 (64.6) | ||||||||
| intron | 30,041,559 | SNP2 | rs9261301 | GG | 29 (33.3) | 18 (34.6) | 0.331 | 1.249 | 0.797–1.957 | |
| AG+AA | 58 (66.7) | 34 (65.4) | ||||||||
| 5′ near gene | 30,043,779 | SNP3 | rs3807032 | GG | 57 (65.5) | 40 (76.9) | 0.617 | 0.893 | 0.574–1.391 | |
| CG+CC | 30 (34.5) | 12 (23.1) | ||||||||
| 5′ near gene | 30,043,955 | SNP4 | rs3807033 | GG | 57 (65.5) | 40 (76.9) | 0.617 | 0.893 | 0.574–1.391 | |
| AG+AA | 30 (34.5) | 12 (23.1) | ||||||||
| 5′ near gene | 30,044,388 | SNP5 | rs3132682 | CC | 28 (32.2) | 17 (32.7) | 0.299 | 1.271 | 0.808–1.999 | |
| CG+GG | 59 (67.8) | 35 (67.3) | ||||||||
| 5′ near gene | 30,044,827 | SNP6 | rs3807035 | GG | 54 (62.1) | 35 (67.3) | 0.729 | 1.080 | 0.699–1.668 | |
| AG+AA | 33 (37.9) | 17 (32.7) | ||||||||
| 5′ near gene | 30,044,914 | SNP7 | rs3807036 | GG | 83 (95.4) | 46 (88.5) | 0.131 | 2.169 | 0.794–5.930 | |
| AG+AA | 4 (4.6) | 6 (11.5) | ||||||||
| 5′ near gene | 30,045,199 | SNP8 | rs1150735 | GG | 47 (54.0) | 28 (53.8) | 0.881 | 1.033 | 0.676–1.578 | |
| AG+AA | 40 (46.0) | 24 (46.2) | ||||||||
HR, hazard ratio; CI, confidental interval.
The p values were adjusted by using a multiple testing correction method for genetic association studies using correlated SNP (Genet Epidemiol. 2008 May;32(4):361–369.).
Bold, emphasizing statistical significance was considered as p value <0.0083 (0.05/6). p-values were obtained by using Cox model analysis.