Figure 1. Ikaros 11 is a novel, non-canonical splice variant of the Ikaros gene.

(A) Diagrammatic representation of Ikaros isoforms 1–10 with their functional domains. (B) Schematic representation of the novel splice variant Ik11. (DBD, DNA Binding Domain; AD, Activation Domain; DD, Dimerization Domain, F1–F6, Zinc Finger modules). (C) Amino acid sequence alignment of the full-length Ik1 and Ik11. Exon positions are indicated. Exon 3B has been previously described [16], [25], [36] but is currently not identified as an exon in Gene Bank.