Table 2.
Systematic review of antibiotic regimens in lower-extremity tumor resection with endoprosthetic reconstruction
| Study | Year | Antibiotic regimens reported |
|---|---|---|
| Eckardt et al. [11] | 1991 | Intravenous antibiotics administered immediately before surgery; continued for 3–4 days postoperatively, until drains removed |
| Roberts et al. [52] | 1991 | Prophylactic antibiotics administered parenterally during surgery |
| Morris et al. [45] | 1995 | Intravenous antibiotics administered preoperatively; continued for 3 days postoperatively when drains removed |
| Abudu et al. [1] | 1996 | Continuous intravenous cefuroxime administered throughout procedure; no postoperative antibiotics given |
| Abudu et al. [2] | 1999 | Continuous intravenous antibiotics (usually cefuroxime) administered throughout surgery |
| Grimer et al. [20] | 1999 | Antibiotics administered at the induction of anesthesia but not repeated |
| Ilyas et al. [30] | 2002 | Antibiotics administered postoperatively for 72 hours |
| Bickels et al. [6] | 2002 | Intravenous prophylactic antibiotics continued until drainage tubes removed |
| Jeys et al. [33] | 2005 | Intravenous broad-spectrum cephalosporin administered preoperatively |
| Sharma et al. [56] | 2006 | Prophylactic antibiotics administered perioperatively for 48 hours |
| Gosheger et al. [17] | 2006 | Prophylactic antibiotics administered locally with a gentamicin-containing collagenous drug carrier; intravenous cephalosporin administered postoperatively for 3 days, followed by oral therapy until wound healed |
| Orlic et al. [51] | 2006 | Prophylactic antibiotics administered perioperatively according to hospital guidelines |
| Myers et al. [47] | 2007 | Prophylactic antibiotics administered at time of surgery; continued for up to 24 hours postoperatively |
| Finstein et al. [13] | 2007 | Intravenous antibiotics (1st-generation cephalosporin) administered preoperatively and for 3 days postoperatively, followed by 5 days of oral antibiotics; antibiotics given while drains in place |
| Myers et al. [46] | 2007 | Prophylactic antibiotics administered at time of surgery; continued for up to 24 hours postoperatively |
| Sewell et al. [55] | 2009 | Intravenous antibiotics continued for 3 days postoperatively |
| Shekkeris et al. [58] | 2009 | Intravenous antibiotics continued for 3 days postoperatively |
| Morii et al. [44] | 2010 | Antibiotics administered preoperatively within 2 hours of surgery; continued for > 72 hours postoperatively |
| Hanna et al. [23] | 2010 | Intravenous antibiotics continued for 3 days postoperatively |
| Hardes et al. [24] | 2010 | Antibiotics administered locally with a gentamicin-containing collagenous drug carrier; intravenous 3rd-generation cephalosporin administered for 3–7 days postoperatively, followed by a 2nd-generation cephalosporin administered orally until wound healed |
| Li et al. [40] | 2011 | Intravenous cephalosporin (1 g) administered intraoperatively; continued for 3 days postoperatively, then administered orally for an additional 5 days |