Table 1.

List of model parameters and values.

Parameter	Value	Units	Description	References
CALCIUM SUBSYSTEM
β	0.0244	−	Buffer Ratio	Bennett et al., 2005
klext	1.0e–4	μMs−1	Rate of flux due to extracellular [Ca2+]	fit
Cext	2000	μM	Extracellular calcium concentration	Valant et al., 1992
jIP3Rmax	100	μMs−1	Max rate of IP3R	Fink et al., 1999
kC	0.06	μM	Calcium dissociation constant from IP3R	Fink et al., 1999
kI	0.02	μM	IP3 dissociation constant from IP3R	Fink et al., 1999
koff	0.75	μMs−1	Inactivation rate of IP3R due to calcium	Fink et al., 1999
kon	0.1	μM	Reactivation rate of IP3R	Fink et al., 1999
jSERCAmax	5.8	μMs−1	Maximum rate of SERCA pump activity	Fink et al., 1999
kSERCA	0.25	μM	Activation [Ca2+] of SERCA pump	Fink et al., 1999
Rvol	5.4	−	Ratio of volumes of Cytosol:ER	Lemon et al., 2003
klER	6e–4	μMs−1	ER leak constant	fit
k1	0.08	μM	threshold for low activity mode of PCA pump	Valant et al., 1992
k2	0.38	μM	threshold for high activity of PCA pump	Valant et al., 1992
V1	1.63	μMs−1	maximal PCA pump rate at low activity	Valant et al., 1992
V2	31.67	μMs−1	maximal PCA pump rate at high activity	Valant et al., 1992
IP3 SUBSYSTEM
kdeg	0.8	s−1	Degradation rate of IP3→ PIP2	Bennett et al., 2005
r*h	0.02	μM μm−2 s−1	GPCR kinetic parameter	Bennett et al., 2005
kATP	15	μM	Dissociation constant for ATP on P2YR	Bennett et al., 2005
kGlu	5	μM	Dissociation constant for Glutamate on P2YR	Bennett et al., 2008
kd	0.15	s−1	Deactivation rate of free G-protein	Bennett et al., 2005
ka	0.017	s−1	Activation rate of free G-protein	Bennett et al., 2005
ATP DIFFUSION AND RELEASE
D	150	μm2 s−1	Diffusivity of ATP	MacDonald et al., 2008
α	−0.35	s−1	ATP degradation rate	MacDonald et al., 2008
krel	0.08	μM	[Ca2+] for 1/2 maximal ATP release	Fit
Cmin	0.02	μM	Min. [Ca2+] for ATP release	Fit
jATPmax	1	μm2 s−1	Max ATP release rate	Fit
σ	0.02	−	Std. Dev. noise	fit