Figure 1.

(A) Longitudinal trends over time of mean values of CRP and LF/HF ratio, reflecting sympathovagal balance, for patients with SOFA > 10, during the 6 days of study period. [log transformed data, adapted from Papaioannou et al. (2009)]. It appears that LF/HF changes inversely with CRP. (B) Longitudinal trends over time of mean values of CRP and SDNN (secs), for patients with SOFA > 10, during the 6 days of study period. [log transformed data, adapted from Papaioannou et al. (2009)]. There is a progressive increase in SOFA score from day 1 until day 4 (development of septic shock) and a subsequent downward shift in its values. At the same time, the variability of heart rate signals estimated with SDNN seems to be significantly reduced during the development of septic shock.