Table 1.
Characteristics of the associations between GWAS-identified SNPs and BMI in populations of European and East Asian Ancestry
| Marker info | Results in European ancestry populations (derived from Speliotes et al. [19]) | Results in East Asian ancestry populations (derived from Wen et al. [39]) | Ancestry of discovery population | Reference(s) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Locus | SNP | Effect allele | Other allele | Effect allele frequency | Effect size | Standard error | P-value | Explained variance (%) | Effect allele frequency | Effect size | Standard error | P-value | Explained variance (%) | ||
| FTO | rs17817449 | g | t | 40% | 0.080 | 0.004 | 1.4E-97 | 0.31% | 17% | 0.085 | 0.008 | 4.6E-27 | 0.20% | European | [14,15] |
| near MC4R | rs6567160 | c | t | 24% | 0.060 | 0.004 | 2.4E-41 | 0.13% | 21% | 0.056 | 0.007 | 2.8E-15 | 0.11% | European and Indian Asian | [16.36] |
| near TMEM18 | rs11127485 | t | c | 83% | 0.060 | 0.005 | 1.3E-33 | 0.10% | 91% | 0.051 | 0.010 | 1.2E-06 | 0.04% | [17,18] | |
| near SEC16B | rs574367 | t | g | 20% | 0.049 | 0.005 | 1.7E-25 | 0.08% | 20% | 0.066 | 0.007 | 9.5E-20 | 0.14% | European | [18] |
| BDNF | rs6265 | c | t | 81% | 0.043 | 0.005 | 2.1E-19 | 0.06% | 44% | 0.045 | 0.006 | 3.6E-13 | 0.10% | European | [18] |
| near GNPDA2 | rs10938397 | g | a | 43% | 0.041 | 0.004 | 2.2E-26 | 0.08% | 29% | 0.037 | 0.007 | 9.7E-08 | 0.06% | European | [17] |
| near ETV5 | rs7647305 | c | t | 79% | 0.039 | 0.005 | 1.2E-16 | 0.05% | 95% | 0.026 | 0.015 | 0.09 | 0.01% | European | [18] |
| near NEGR1 | rs2568958 | a | g | 61% | 0.033 | 0.004 | 8.7E-18 | 0.05% | 92% | 0.023 | 0.011 | 0.04 | 0.01% | European | [17,18] |
| near FAIM2 | rs7138803 | a | g | 38% | 0.032 | 0.004 | 4.2E-17 | 0.05% | 31% | 0.020 | 0.006 | 1.7E-03 | 0.02% | European | [18] |
| SH2B1 | rs4788102 | a | g | 40% | 0.029 | 0.004 | 1.0E-13 | 0.04% | 13% | 0.024 | 0.009 | 6.5E-03 | 0.01% | European | [17,18] |
| MTCH2 | rs3817334 | t | c | 41% | 0.024 | 0.004 | 1.9E-10 | 0.03% | 31% | 0.024 | 0.006 | 1.8E-04 | 0.02% | European | [17] |
| near KCTD15 | rs29941 | g | a | 67% | 0.021 | 0.004 | 1.1E-07 | 0.02% | 23% | 0.007 | 0.007 | 0.30 | 0.00% | European | [17,18] |
| near PRKD1 | rs11847697 | t | c | 4% | 0.053 | 0.010 | 2.8E-07 | 0.02% | 0% | European | [29] | ||||
| SLC39A8 | rs13107325 | t | c | 7% | 0.046 | 0.008 | 2.6E-08 | 0.03% | 0% | European | [29] | ||||
| TFAP2B | rs4715210 | t | c | 17% | 0.043 | 0.005 | 3.9E-18 | 0.05% | 21% | 0.038 | 0.007 | 1.6E-07 | 0.05% | European | [29] |
| near GPRC5B | rs12444979 | c | t | 86% | 0.042 | 0.006 | 2.5E-13 | 0.04% | 0% | European | [29] | ||||
| GIPR-QPTCL | rs2287019 | c | t | 80% | 0.032 | 0.005 | 1.4E-09 | 0.03% | 79% | 0.016 | 0.008 | 0.05 | 0.01% | European | [29] |
| MAP2K5 | rs2241423 | g | a | 78% | 0.032 | 0.004 | 1.0E-12 | 0.03% | 38% | 0.031 | 0.006 | 2.3E-09 | 0.05% | European | [29] |
| near ADCY3/RBJ | rs713586 | c | t | 47% | 0.030 | 0.004 | 3.1E-15 | 0.05% | 46% | 0.029 | 0.007 | 1.4E-13 | 0.04% | European | [29] |
| near FLJ35779 (HMGCR) | rs2112347 | t | g | 63% | 0.029 | 0.005 | 1.0E-13 | 0.04% | 44% | 0.018 | 0.006 | 3.9E-03 | 0.02% | European | [29] |
| near TMEM160 | rs3810291 | a | g | 67% | 0.028 | 0.005 | 5.1E-11 | 0.04% | 24% | 0.035 | 0.008 | 2.7E-05 | 0.04% | European | [29] |
| near LRP1B | rs2890652 | c | t | 18% | 0.028 | 0.005 | 3.6E-08 | 0.02% | 0% | European | [29] | ||||
| MTIF3 | rs4771122 | g | a | 24% | 0.027 | 0.005 | 2.0E-09 | 0.03% | 22% | 0.005 | 0.009 | 0.62 | 0.00% | European | [29] |
| CADM2 | rs13078807 | g | a | 20% | 0.026 | 0.005 | 3.9E-08 | 0.02% | 0% | European | [29] | ||||
| near FANCL | rs887912 | t | c | 29% | 0.024 | 0.004 | 6.3E-09 | 0.02% | 0% | European | [29] | ||||
| LRRN6C | rs10968576 | g | a | 32% | 0.024 | 0.004 | 2.5E-09 | 0.03% | 19% | 0.009 | 0.008 | 0.28 | 0.00% | European | [29] |
| NRXN3 | rs10150332 | c | t | 22% | 0.024 | 0.005 | 1.5E-07 | 0.02% | 0% | European | [29] | ||||
| near PTBP2 | rs1555543 | c | a | 59% | 0.024 | 0.005 | 5.2E-10 | 0.03% | 87% | 0.005 | 0.009 | 0.57 | 0.00% | European | [29] |
| TNNI3K | rs1514175 | a | g | 43% | 0.023 | 0.005 | 1.0E-09 | 0.03% | 79% | 0.029 | 0.007 | 6.4E-05 | 0.03% | European | [29] |
| NUDT3 | rs206936 | g | a | 20% | 0.020 | 0.005 | 3.3E-05 | 0.01% | 56% | 0.008 | 0.006 | 0.22 | 0.00% | European | [29] |
| near ZNF608 | rs4836133 | a | c | 48% | 0.018 | 0.005 | 6.4E-06 | 0.02% | 0% | European | [29] | ||||
| near RPL27A | rs4929949 | c | t | 52% | 0.018 | 0.005 | 1.6E-06 | 0.02% | 43% | 0.018 | 0.007 | 0.01 | 0.02% | European | [29] |
| GIPR/QPTCL | rs11671664 | g | a | 89% | 0.029 | 0.009 | 1.2E-03 | 0.02% | 50% | 0.044 | 0.006 | 5.9E-14 | 0.10% | East Asian | [38,39] |
| near KLF9 | rs11142387 | c | a | 53% | 0.003 | 0.005 | 0.45 | 0.00% | 46% | 0.040 | 0.007 | 1.3E-09 | 0.08% | East Asian | [38] |
| near GP2 | rs12597579 | c | t | 95% | 0.028 | 0.011 | 9.0E-03 | 0.01% | 80% | 0.036 | 0.006 | 1.0E-08 | 0.04% | East Asian | [39] |
| CDKAL1 | rs9356744 | t | c | 68% | 0.007 | 0.005 | 0.19 | 0.00% | 58% | 0.034 | 0.005 | 2.0E-11 | 0.06% | East Asian | [38,39] |
| near PCSK1 | rs261967 | c | a | 43% | 0.015 | 0.005 | 1.6E-03 | 0.01% | 41% | 0.031 | 0.005 | 5.1E-09 | 0.05% | East Asian | [39] |
The table includes 32 SNPs identified in European Ancestry populations [14-19,36] and four SNPs identified in East Asian ancestry populations [38,39], sorted by year of discovery and subsequently by effect size in the population in which discovery was made. Data were obtained and adapted from Speliotes et al. [19] and from Wen et al. [39].