Figure 2.

Amyloid plaques in brains of mice and the effect of curcuminoid injections. (A) Time course of curcuminoid injections into Alzheimer transgenic mice. Arrowhead denotes the time point when serum-solubilized curcuminoids were switched to HP-γ-CD-solubilized curcuminoids, asterisk when i.v. injections were replaced with s.c. injections. (B) Silver stained brain section from a control non-transgenic mouse without plaques. (C) Comparable section from an Alzheimer transgenic mouse at the age of 12 months. (D) The effect of curcuminoid injections on amyloid plaque load. Left panel: Alzheimer transgenic control mice were analyzed at 12 months of age and received either no injections (n = 3), or injection of vehicle alone according to the protocols for plaque prevention (n = 3) or plaque resolution (n = 3). The differences in the relative plaque levels in each of the groups were not statistically different and the values were combined and assigned the value of 100% (n = 9). Right panel: The combined control group was compared to experimental mice that had been injected for plaque prevention (n = 6) or plaque resolution (n = 7) with a statistical difference defined at the level of P < 0.05 (*P = 0.0496).