Table 4.
Results of separate multiple linear regression models with ventilator-free days, ICU-free days, and specific organ failure-free days as the outcome variables and GDF-15 quartile as the predictor variable.
| Quartile 2 | Quartile 3 | Quartile 4 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| β* | 95% CI | P value | β * | 95% CI | P value | β * | 95% CI | P value | |
| Ventilator-free days | -2.91 | -5.61, -0.21 |
0.03 | -5.27 | -8.01, -2.53 |
<0.01 | -6.56 | -9.38, -3.74 | <0.01 |
| ICU-free days | -1.88 | -4.39, 0.62 | 0.14 | -5.25 | -7.81, -2.71 |
<0.01 | -6.25 | -8.87, -3.63 | <0.01 |
| Organ failure-free days | |||||||||
| Cardiovascular | -0.85 | -3.32, 1.61 | 0.50 | -2.38 | -4.87, 0.12 | 0.06 | -6.03 | -8.61, -3.45 | <0.01 |
| CNS | -2.03 | -4.78, 0.72 | 0.15 | -5.66 | -8.44, -2.88 |
<0.01 | -8.69 | -11.56, -5.81 |
<0.01 |
| Coagulation | -0.19 | -2.60, 2.22 | 0.88 | -3.03 | -5.46, -0.59 |
0.02 | -7.49 | -10.01, -4.97 |
<0.01 |
| Renal | -0.45 | -2.87, 1.98 | 0.72 | -4.73 | -7.18, -2.27 |
<0.01 | -10.0 | -12.56, -7.49 |
<0.01 |
| Hepatic | -0.01 | -2.42, 2.41 | 0.99 | -2.52 | -4.96, -0.07 | 0.04 | -8.49 | -11.02, -5.97 |
< 0.01 |
Patients in GDF-15 quartile 1 served as the control group and, therefore, are not included in the table. *Parameter estimates shown are the difference when compared to patients in GDF-15 quartile 1 after adjusting for APACHE III score. CNS, central nervous system; 95% CI, 95% confidence interval.