Table 3.
LH-Regulated Genes Specific to TCs
| Gene Name or Chromosomal Location | Gene Symbola | Fold Change | HSI − Mean RMA Hybridization Value |
|
|---|---|---|---|---|
| Before LH | After LH | |||
| Cytochrome P450c17, 17α-hydroxylase/17;20 lyase | CYP17A1 | −77.1 | 3452 | 45 |
| Ankyrin repeat and sterile α motif domain containing 4B | ANKS4B | −19.1 | 234 | 12 |
| Solute carrier family 1; member 3 | SLC1A3 | −10.5 | 195 | 19 |
| chr16:69743779-69744290 (−) | (TRAF5) | −9.5 | 107 | 11 |
| Chemokine (C-X-C motif) ligand 14 | CXCL14 | −9.2 | 142 | 15 |
| Tetraspanin 33 | TSPAN33 | −8.8 | 270 | 31 |
| Crystallin; μ | CRYM | −7.8 | 328 | 42 |
| Hydroxyprostaglandin dehydrogenase 15-(NAD) | HPGD | −7.1 | 875 | 124 |
| Asporin | ASPN | −6.5 | 709 | 109 |
| dCTP pyrophosphatase 1 | DCTPP1 | −5.5 | 2181 | 400 |
| Oncoprotein induced transcript 3 | OIT3 | −5.0 | 222 | 45 |
| ChrUn_JH123563:7386-7628 - AffyID Bt.16424.1.S1_at | — | −4.9 | 609 | 124 |
| Transmembrane 7 superfamily member 2 | TM7SF2 | −4.7 | 624 | 132 |
| Ryanodine receptor 3 | RYR3 | −4.5 | 85 | 19 |
| Pyridine nucleotide-disulfide oxidoreductase domain 2 | PYROXD2 | −4.4 | 216 | 50 |
| Angiopoietin 4 | ANGPT4 | −4.0 | 192 | 48 |
| BCL2-related protein A1 | BCL2A1 | −3.9 | 193 | 49 |
| Protein phosphatase 2; regulatory subunit B; β | PPP2R2B | −3.9 | 45 | 12 |
| Perilipin 5 | PLIN5 | −3.7 | 44 | 12 |
| chr5:17947935-17948135 (−) | — | −3.7 | 28 | 8 |
| Guanylate binding protein 4 | GBP4 | −3.7 | 106 | 29 |
| Transient receptor potential cation channel, subfamily M, member 4 | TRPM4 | −3.3 | 102 | 30 |
| Chemokine (C-C motif) ligand 26 | CCL26 | −3.3 | 135 | 41 |
| Small integral membrane protein 10 | SMIM10 | −3.1 | 147 | 48 |
| Cytochrome P450; family 4; subfamily F; polypeptide 3 | CYP4F3 | −3.0 | 64 | 21 |
| Potassium large conductance calcium-activated channel; subfamily M; β member 1 | KCNMB1 | −3.0 | 52 | 18 |
| Nuclear receptor subfamily 5; group A; member 1 | NR5A1 | −2.8 | 642 | 229 |
| Similar to DKFZP586J0619 protein | INTS1 | −2.6 | 347 | 131 |
| ADP-ribosyltransferase 3 | ART3 | −2.6 | 94 | 36 |
| NLR family; CARD domain containing 5 | NLRC5 | −2.6 | 59 | 23 |
| Gap junction protein; β 5; 31.1 kDa | GJB5 | −2.5 | 243 | 98 |
| Diacylglycerol O-acyltransferase homolog 2 (mouse) | DGAT2 | −2.2 | 41 | 18 |
| Carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 | CHST1 | −2.2 | 228 | 102 |
| Mevalonate kinase | MVK | −2.0 | 571 | 288 |
| Fibroblast growth factor 1 (acidic) | FGF1 | −1.9 | 30 | 16 |
| RAN guanine nucleotide release factor | RANGRF | −1.9 | 115 | 60 |
| Mitochondrial ribosome recycling factor | MRRF | −1.9 | 445 | 233 |
| chr29:48560683-48560989 (+) | (CCND1) | −1.9 | 23 | 12 |
| ATP synthase subunit g, mitochondrial-like | ATP5 liter | −1.7 | 2599 | 1561 |
| Solute carrier family 25; member 34 | SLC25A34 | −1.7 | 33 | 20 |
| Solute carrier family 25: member 23 | SCL25A23 | −1.6 | 67 | 41 |
| Fragile X mental retardation; autosomal homolog 1 | FXR1 | −1.6 | 1542 | 970 |
| Kruppel-like factor 10 | KLF10 | 2.3 | 581 | 1311 |
| ras Homolog gene family; member B | RHOB | 2.4 | 1375 | 3341 |
| chr19:32921507-32921922 (+) | (Hs3st3b1) | 2.6 | 10 | 25 |
| chr11:86149219-86149711 (−) | (FAM84A) | 2.7 | 23 | 60 |
| Chromosome 21 open reading frame 7 ortholog | C1H21ORF7 | 2.9 | 18 | 52 |
| Adenomatosis polyposis coli down-regulated 1 | APCDD1 | 3.0 | 71 | 213 |
| Carbonic anhydrase IV | CA4 | 3.8 | 45 | 169 |
| chr8:52926349-52926740 (+) | (Rorb) | 3.9 | 11 | 42 |
| Coagulation factor V (proaccelerin; labile factor) | F5 | 4.0 | 13 | 53 |
| chr8:26339534-26340004 (−) | (Acer2) | 4.3 | 78 | 340 |
| Nuclear protein; transcriptional regulator; 1 | NUPR1 | 4.9 | 63 | 306 |
| ATP-binding cassette; subfamily G (WHITE); member 1 | ABCG1 | 6.9 | 14 | 93 |
| Solute carrier family 7; member 5 | SLC7A5 | 7.7 | 54 | 419 |
| Ceruloplasmin (ferroxidase) | CP | 8.2 | 20 | 166 |
| Lysyl oxidase-like 4 | LOXL4 | 18.8 | 98 | 1847 |
a
Gene symbols enclosed in parentheses are probes sets that recognize transcripts with high homology to a named gene in another species.
Chromosomal locations are based on the Cow October 2011 assembly. Dashes reflect a negative or down regulated gene.