Table 2.
Association of mammographic measures with risk of breast cancer when using sister controls or unrelated controlsa
| Sister controls (n = 228 pairs) | Unrelated controls (n = 228 pairs) | ||||||
|---|---|---|---|---|---|---|---|
| Inter-quintile rangeb | Βeta (SE) | P value | Inter-quintile OR (95% CI)c |
Βeta (SE) | P value | Inter-quintile OR (95% CI) |
|
| Percent density | 10.0 - 48.1 | 0.2062 (0.0810) | 0.01 | 2.19 (1.20, 4.00) | 0.2538 (0.0648) | <.0001 | 2.62 (1.62, 4.25) |
| Dense area | 11.0 - 50.6 | 0.1499 (0.0607) | 0.01 | 1.77 (1.12, 2.78) | 0.2365 (0.0510) | <.0001 | 2.46 (1.68, 3.59) |
| Non-dense area | 45.1 - 136.7 | -0.1364 (0.0598) | 0.02 | 0.51 (0.28, 0.91) | -0.0142 (0.0520) | 0.78 | 0.93 (0.56, 1.55) |
| Total area | 77.3 - 165.0 | -0.0591 (0.0633) | 0.35 | 0.79 (0.47, 1.31) | 0.1483 (0.0596) | 0.01 | 1.84 (1.14, 2.97) |
aAll coefficients are based on square root transformed mammogram measures; binter-quintile range from unrelated controls, on the untransformed mammographic measures; cinter-quintile odds ratio (95% confidence interval (CI)) is based on the inter-quintile range of square root transformed mammogram measures, adjusted for age at mammogram, parity, menopausal status, hormone usage (never, ever but not now, current using), and body mass index. OR, odds ratio; SD, standard error.