Table 1.
Variables of cardiovascular hemodynamics
| Variable | Time point | sham | control | rhAT |
|---|---|---|---|---|
| CI | BL | 6.1 (5.6; 6.7) | 5.9 (5.7; 6.7) | 6.8 (6.1; 7.8) |
| (L/min/m2) | 6 h | 6.7 (6.0; 7.5) | 6.2 (5.3; 7.2) | 6.7 (5.6; 7.5) |
| 12 h | 6.9 (6.4; 7.0) | 6.0 (4.7; 7.4) | 7.8 (6.9; 8.4) | |
| 24 h | 7.1 (6.6; 7.4) | 5.5 (5.0; 5.6)# | 8.0 (6.8; 8.8)† | |
| 36 h | 6.2 (5.4; 7.3) | 5.6 (5.3; 6.4) | 6.7 (6.3; 7.8) | |
| 48 h | 6.5 (6.4; 6.9) | 4.5 (4.4; 7.2) | 6.7 (5.8; 7.7) | |
| MAP | BL | 97 (93; 98) | 101 (93; 113) | 105 (96; 110) |
| (mmHg) | 6 h | 100 (94; 102) | 103 (99; 108) | 104 (96; 108) |
| 12 h | 95 (91; 104) | 100 (98; 109) | 102 (94; 102) | |
| 24 h | 92 (89; 98) | 102 (99; 107) | 95 (93; 106) | |
| 36 h | 92 (87; 98) | 100 (89; 104) | 103 (100; 108) | |
| 48 h | 93 (90; 98) | 101 (90; 111) | 101(99; 106) | |
| CVP | BL | 5 (5; 5) | 6 (5; 8) | 5 (4; 6) |
| (mmHg) | 6 h | 7 (6; 11) | 9 (7; 10) | 9 (8; 10) |
| 12 h | 9 (5; 10) | 10 (7; 11) | 9 (7; 9) | |
| 24 h | 8 (7; 10) | 12 (10; 14)*# | 7 (5; 11) | |
| 36 h | 10 (7; 11) | 13 (12; 14)*# | 7 (6; 10)† | |
| 48 h | 9 (9; 11) | 11 (7; 13) | 6 (5; 8) | |
| LAP | BL | 7 (6; 8) | 9 (8; 10) | 9 (9; 10) |
| (mmHg) | 6 h | 9 (9; 9) | 9 (7; 11) | 10 (8; 12) |
| 12 h | 12 (11; 12) | 11 (9; 13) | 11 (9; 12) | |
| 24 h | 11 (10; 12) | 12 (11; 13)* | 10 (9; 11) | |
| 36 h | 12 (9; 13) | 14 (13; 16)* | 10 (8; 14) | |
| 48 h | 11 (9; 13) | 17 (15; 18)*# | 8 (7; 9)† | |
| LVSWI | BL | 77 (67; 87) | 75 (67; 83) | 86 (73; 93) |
| (g/m/m2) | 6 h | 78 (57; 89) | 57 (45; 75) | 79 (64; 86) |
| 12 h | 66 (64; 72) | 50 (44; 60)* | 74 (60; 91) | |
| 24 h | 67 (59; 77) | 35 (34; 37)*# | 71 (56; 80)† | |
| 36 h | 71 (65; 76) | 35 (31; 43)*# | 73 (61; 86)† | |
| 48 h | 73 (72; 76) | 43 (42; 55)*# | 66 (63; 73)† | |
| RVSWI | BL | 13 (13; 14) | 12 (10; 15) | 13 (11; 15) |
| (g/m/m2) | 6 h | 13 (11; 17) | 13 (10; 15) | 13 (11; 17) |
| 12 h | 16 (14; 17) | 13 (11; 16) | 16 (14; 18) | |
| 24 h | 15 (15; 17) | 9 (8; 11)# | 15 (11; 17) | |
| 36 h | 16 (14; 17) | 8 (7; 12)# | 13 (13; 17) | |
| 48 h | 15 (13; 16) | 10 (9; 12) | 16 (11; 19) | |
*, P <0.05 vs. BL; #, P <0.05 vs. sham; † , P <0.05 vs. control; data are represented as median with interquartile range (25th; 75th); each group n = 6
BL, baseline; CI, cardiac index; CVP, central venous pressure; LAP, left atrial pressure; LVSWI, left ventricular stroke work index; MAP, mean arterial pressure; rhAT, recombinant human antithrombin III; RVSWI, right ventricular stroke work index.