Table 2.
Hematocrit, plasma protein concentration, oncotic pressure, urine flow, creatinine clearance and antithrombin plasma levels
| Variable | Time point | sham | control | rhAT |
|---|---|---|---|---|
| Hematocrit | BL | 27 (22; 29) | 24 (23; 27) | 26 (21; 26) |
| (%) | 6 h | 23 (22; 26) | 27 (23; 29) | 25 (21; 26) |
| 12 h | 26 (23; 30) | 28 (24; 31) | 26 (24; 27) | |
| 24 h | 25 (24; 27) | 30 (27; 32) | 27 (22; 27) | |
| 36 h | 23 (23; 26) | 29 (28; 36)*# | 27 (27; 28) | |
| 48 h | 22 (21; 25) | 27 (24; 35) | 26 (24; 29) | |
| Protein | BL | 6.1 (6.0; 6.2) | 6.2 (5.8; 6.6) | 6.1 (6.0; 6.4) |
| (g/dL) | 6 h | 5.7 (5.6; 6.0) | 4.9 (4.6; 5.0)*# | 5.0 (4.6; 5.4)*# |
| 12 h | 6.1 (5.9; 6.4) | 4.5 (4.4; 4.6)*# | 4.9 (4.8; 5.0)*#† | |
| 24 h | 5.9 (5.8; 6.2) | 4.0 (4.0; 4.0)*# | 4.6 (4.6; 4.6)*#† | |
| 36 h | 5.9 (5.7; 6.2) | 3.6 (3.6; 3.9)*# | 4.7 (4.6; 5.0)*#† | |
| 48 h | 5.6 (5.6; 5.8) | 3.8 (3.5; 3.9)*# | 5.0 (4.5; 5.3)*#† | |
| Oncotic pressure | BL | 19 (17; 20) | 19 (18; 20) | 20 (19; 22) |
| (cmH2O) | 6 h | 18 (16; 19) | 13 (12; 14)*# | 14 (13; 16)*# |
| 12 h | 18 (16; 20) | 12 (11; 13)*# | 14 (13; 15)*# | |
| 24 h | 19 (16; 20) | 10 (9; 10)*# | 13 (12; 14)*#† | |
| 36 h | 19 (16; 20) | 9 (9; 11)*# | 13 (13; 15)*#† | |
| 48 h | 17 (15; 18) | 9 (9; 10)*# | 13 (12; 15)*#† | |
| Urine flow | BL | / | / | / |
| (mL/kg/h) | 6 h | 7.7 (6.8; 8.3) | 3.4 (2.5; 4.3)# | 3.2 (1.6; 4.7)# |
| 12 h | 7.4 (4.5; 9.0) | 2.7 (2.0; 4.5)# | 2.7 (2.4; 3.8)# | |
| 24 h | 4.5 (2.7; 5.7) | 1.2 (1.1; 2.0)# | 4.0 (3.0; 5.2)† | |
| 36 h | 2.3 (2.0; 2.9) | 0.6 (0.3; 0.8)# | 4.1 (3.7; 5.4)#† | |
| 48 h | 2.4 (2.1; 2.5) | 0.8 (0.8; 0.9)# | 3.3 (2.6; 3.8)† | |
| Creatinine clearance | BL | / | / | / |
| (mL/min) | 6 h | / | / | / |
| 12 h | 105 (97; 129) | 89 (78; 141) | 78 (76; 124) | |
| 24 h | 88 (78; 176) | 84 (71; 94) | 100 (91; 115) | |
| 36 h | 107 (84; 135) | 104 (74; 122) | 120 (106; 134) | |
| 48 h | 102 (81; 112) | 91 (88; 94) | 96 (82; 115) | |
| AT plasma level | BL | 86 (83; 89) | 79 (72; 82) | 87 (73; 93) |
| (mg/L) | 6 h | 86 (81; 89) | 58 (57; 59)*# | 88 (83; 89)† |
| 12 h | 87 (83; 91) | 52 (50; 55)*# | 85 (81; 95)† | |
| 24 h | 86 (73; 88) | 45 (40; 50)*# | 83 (75; 84)† | |
| 36 h | 86 (76; 88) | 47 (40; 48)*# | 86 (80; 87)† | |
| 48 h | 83 (75; 88) | 52 (47; 54)*# | 84 (73; 87)† | |
*, P <0.05 vs. BL; #, P <0.05 vs. sham; † , P <0.05 vs. control; data are represented as median with interquartile range (25th; 75th); each group n = 6
AT, antithrombin; BL, baseline; rhAT, recombinant human antithrombin III