Figure 1.
Rassf1a-deficient Apc+/Min mice show increased intestinal adenoma formation. At 16 weeks of age intestines were collected from Rassf1a+/+ (n=11), Rassf1a+/− (n=21) and Rassf1a−/− (n=30) mice on an Apc+/Min background. (a) The intestines were opened and analysed for number and location of adenomas (polyps) with the help of a dissecting microscope. The bar indicates mean value for each genotype. (b) The intestines were then prepared as Swiss-rolls and histologically analysed following haematoxylin-eosin staining (circles outline the adenomas). All sections shown are representative. Magnification: x25.