Figure 2.

Rassf1a-deficient Apc^+/Min mice show decreased survival. (a) Kaplan-Meier plots show the percentages of survival of Rassf1a^+/+, Rassf1a^+/− and Rassf1a^−/− mice on an Apc^+/Min background. (b) When the mice became moribund, their intestines were collected and prepared as Swiss-rolls for histological analysis following haematoxylin-eosin staining. The processed intestines from Rassf1a^+/+; Apc^+/Min (n=33) and Rassf1a^−/−; Apc^+/Min (n=52) were analysed for the presence of adenomas (grouped into grades 1-3 based on their number and degree of dysplasia) and adenocarcinomas. (c) The age at death for mice bearing intestinal adenocarcinomas was compared between Rassf1a^+/+; Apc^+/Min (n=6) and Rassf1a^−/−; Apc^+/Min (n=9) mice. The bar indicates mean value for each genotype.