Table 1.

Localization of Different Types of Voltage-gated Sodium Channels in Human Organism

Type of Sodium Channel α-Subunit	Human Gene	Localization	Disease
NaV1.1	SCN1A	Brain: neuronal somata, proximal dendrites [2, 12]	Epilepsy
NaV1.2	SCN2A	Brain: predominantly along axons: unmyelinated and myelinated [2], axon initial segments [13]	Epilepsy
NaV1.3	SCN3A	Brain: neuronal somata, proximal dendrites; [2, 12], upregulated expression in epileptic hippocampal neurons [14]	Epilepsy, Central neuropathic pain [15]
NaV1.4	SCN4A	Skeletal muscle [2]
NaV1.5	SCN5A	Cardiac muscle; some neurons [2], microglial cells [16]	Atrial fibrillation, ventricular fibrillation [10]
NaV1.6	SCN8A	Brain: axon initial segments, nodes of Ranvier, neuronal somata, dendrites of projection neurons [2] proximal dendrites [12], unmyelinated and myelinated axons [17]	Ataxia
NaV1.7	SCN9A	Peripheral primary sensory neurons [2] Trigeminal ganglion neurons [18]	Neuropathic pain
NaV1.8	SCN10A
NaV1.9	SCN11A