Table 3.

Binding Affinities, Pharmacological Properties and Proposed Biding Sites of LTG and Similar Compounds [54]

	KD [µM] Rat Brain Na+ Channels (NaV1.2) Expressed in Xenopus oocytes in Inactivated State (- 50 mV)	Pharmacological Properties in Preclinical Evaluation	Position of Amino Acid Residues in IV- S6 Binding Site
	17.3	Analgesic but no anticonvulsant activity	1764 – strong interaction
			1771 – strong interaction
			1760 – weaker interaction
	3.7	Analgesic and anticonvulsant activity	1764 – much stronger interaction;
			1771 – modest interaction;
			1760 weaker interaction
	10.3	Prevention of neuronal toxicity following stroke	1764 – strong interaction;
			1771 – weak interaction;
			1760 – weak interaction;
			Possible interactions with amino acid
			Residues in other transmembrane segments