Table 3.
Gene ontology analysis of validated mmu-miR-33-5p target genes.
| GO ID | GO term | Annotated genes | Corr. p-value |
| GO MOLECULAR FUNCTION | |||
| GO:0005488 | Binding | Zp3, Lin28, Hprt1, Mos, H2afx, Ctdspl, H2afz, Fas, Rfpl4, Mt1, Ccnb2, Mbp, Dppa3, H1foo, Cd320, Dicer1, Hnt, Cpeb1, Srebf2, Ldlr, Cpt1a, Bmp4, Camk2g, Fgf21, Ccne1, Dnmt3b, Sycp3, Sirt6, Pou5f1, Abcg1 | 1.02E−06 |
| GO:0035198 | miRNA binding | Dicer1, Lin28, Pou5f1 | 8.49E−06 |
| GO:0097159 | Organic cyclic compound binding | H1foo, Cd320, Dicer1, Cpeb1, Srebf2, Lin28, Hprt1, Camk2g, Mos, H2afx, H2afz, Dnmt3b, Sycp3, Sirt6, Pou5f1, Abcg1 | 5.09E−03 |
| GO:0005515 | Protein binding | Zp3, Lin28, Hprt1, H2afx, H2afz, Fas, Rfpl4, Ccnb2, Mbp, Dppa3, Cd320, Dicer1, Cpeb1, Srebf2, Ldlr, Cpt1a, Bmp4, Camk2g, Fgf21, Ccne1, Dnmt3b, Sycp3, Abcg1, Pou5f1 | 1.02E−06 |
| GO BIOLOGICAL PROCESS | |||
| GO:0000003 | Reproduction | H1foo, Dicer1, Zp3, Cpeb1, Lin28, Bmp4, Mos, H2afx, Ifitm3, Sycp3 | 5.11E−04 |
| GO:0048610 | Cellular process involved in reproduction | H1foo, Zp3, Cpeb1, Lin28, Sycp3, Bmp4, Mos, H2afx | 4.52E−05 |
| GO:0032502 | Developmental process | Zp3, Lin28, Hprt1, H2afz, Fas, Ccnb2, Mbp, Dppa3, Hnt, Dicer1, Bmp4, Camk2g, Ccne1, Dnmt3b, Sycp3, Abcg1, Pou5f1 | 3.72E−03 |
| GO:0042221 | Response to chemical stimulus | Mbp, Dicer1, Srebf2, Lin28, Hprt1, Bmp4, Fgf21, Ifitm3, Fas, Dnmt3b, Mt1, Abcg1, Pou5f1 | 2.83E−03 |
| GO:0071840 | Cellular component organization or biogenesis | Hprt1, H2afx, H2afz, Fas, Ccnb2, Mbp, H1foo, Dppa3, Hnt, Dicer1, Cpeb1, Cpt1a, Bmp4, Dnmt3b, Sycp3, Abcg1, Pou5f1, Sirt6 | 1.33E−04 |
| GO:0003133 | Endodermal-mesodermal cell signaling | Bmp4, Pou5f1 | 3.54E−03 |
| GO:0006325 | Chromatin organization | Dppa3, H1foo, H2afx, H2afz, Sycp3, Dnmt3b, Pou5f1, Sirt6 | 1.36E−04 |
| GO:0006259 | DNA metabolic process | Dppa3, H1foo, Bmp4, H2afx, Ccne1, H2afz, Sycp3, Dnmt3b, Sirt6 | 2.32E−04 |
| GO:0022402 | Cell cycle process | H1foo, Dicer1, Cpeb1, Camk2g, Bmp4, Mos, H2afx, Sycp3, Ccnb2 | 5.36E−04 |
| GO:0045595 | Regulation of cell differentiation | Mbp, Dicer1, Hnt, Lin28, Bmp4, Ccne1, Fas, Dnmt3b, Pou5f1, Abcg1 | 6.50E−04 |
| GO:0007049 | Cell cycle | H1foo, Dicer1, Cpeb1, Camk2g, Bmp4, Mos, H2afx, Ccne1, Sycp3, Ccnb2 | 1.05E−03 |
| GO:0006807 | Nitrogen compound metabolic process | Zp3, Lin28, Hprt1, H2afx, H2afz, H1foo, Dppa3, Dicer1, Srebf2, Cpeb1, Cpt1a, Ldlr, Bmp4, Ccne1, Dnmt3b, Sycp3, Abcg1, Pou5f1, Sirt6 | 1.44E−03 |
| GO:0040029 | Regulation of gene expression, epigenetic | Dppa3, Dicer1, Dnmt3b, Lin28, Pou5f1 | 1.29E−03 |
| GO:0048519 | Negative regulation of biological process | Mbp, Dppa3, Dicer1, Zp3, Hnt, Srebf2, Lin28, Bmp4, Ifitm3, Fas, Dnmt3b, Mt1, Sycp3, Pou5f1, Abcg1 | 1.78E−03 |
| GO:0045834 | Positive regulation of lipid metabolic process | Zp3, Ldlr, Cpt1a, Abcg1 | 7.65E−03 |
| GO:0016458 | Gene silencing | Dicer1, Dnmt3b, Lin28, Pou5f1 | 7.65E−03 |
| GO:0010033 | Response to organic substance | Dicer1, Srebf2, Lin28, Hprt1, Bmp4, Fgf21, Ifitm3, Fas, Dnmt3b, Abcg1, Pou5f1 | 4.09E−03 |
| GO:0050794 | Regulation of cellular process | Zp3, Lin28, Hprt1, Mos, Ifitm3, Fas, Mt1, Ccnb2, Mbp, Dppa3, Hnt, Dicer1, Cpeb1, Srebf2, Ldlr, Cpt1a, Bmp4, Fgf21, Ccne1, Dnmt3b, Sycp3, Sirt6, Abcg1, Pou5f1 | 4.26E−03 |
| GO:0071824 | Protein-DNA complex subunit organization | H1foo, H2afz, Sycp3, H2afx | 5.38E−03 |
| GO:0080090 | Regulation of primary metabolic process | Dppa3, Dicer1, Zp3, Cpeb1, Srebf2, Ldlr, Cpt1a, Lin28, Hprt1, Bmp4, Ccne1, Dnmt3b, Sirt6, Pou5f1, Ccnb2, Abcg1 | 7.43E−03 |
| GO:0006323 | DNA packaging | H1foo, H2afz, Sycp3, H2afx | 7.37E−03 |
| GO:0003130 | BMP signaling pathway involved in heart induction | Bmp4, Pou5f1 | 3.54E−03 |
| GO:0034641 | Cellular nitrogen compound metabolic process | Zp3, Lin28, Hprt1, H2afx, H2afz, H1foo, Dppa3, Dicer1, Srebf2, Cpeb1, Cpt1a, Ldlr, Bmp4, Ccne1, Dnmt3b, Sycp3, Abcg1, Pou5f1, Sirt6 | 5.92E−04 |
| GO:0050793 | Regulation of developmental process | Mbp, Dicer1, Zp3, Hnt, Lin28, Bmp4, Ccne1, Fas, Dnmt3b, Pou5f1, Abcg1 | 1.71E−03 |
| GO:0048523 | Negative regulation of cellular process | Mbp, Dppa3, Dicer1, Zp3, Hnt, Srebf2, Lin28, Bmp4, Ifitm3, Fas, Dnmt3b, Mt1, Sycp3, Pou5f1, Abcg1 | 4.54E−04 |
Indicated are gene ontology IDs (GO ID), gene ontology terms (GO term), the annotated gene names, and corrected p-values as determined by GenericGeneOntologyTermFinder (http://go.princeton.edu/cgi-bin/GOTermFinder) and REViGO (http://revigo.irb.hr/).