Table 1.
Summary of some recent multiplex Alzheimer's disease biomarker studies
| Author | Technique | Biomarkers |
|---|---|---|
| Doecke et al. [41] | Multiplex panel: Human Discover MAP, version 1.0; RBM | 151 multiplexed analytes |
| Watt et al. [47] | Copper immobilized metal affinity capture and SELDI | Three candidate biomarkers in blood |
| Ray et al. [40] | Filter based, arrayed sandwich-ELISA | Chemokines, growth factors, and inflammation markers |
| Zhang et al. [48] | Multidimensional LC in combination with one- and two-dimensional PAGE | Serum-based biomarkers |
| MALDI and ESI-MS | Inflammatory response mediators | |
| ELISA multiplex platforms | Amyloid beta | |
| Henkel et al. [49] | Anion exchange and reverse phase chromatography | 12 high-abundance proteins from plasma |
| Choi et al. [50] | Two-dimensional PAGE, western blot, and MALDI-MS | Fibrinogen gamma chain and alpha1 antitrypsin |
| Lopez et al. [51] | Affinity chromatography, spin columns and MALDI-MS | Pattern of unidentified proteins in serum |
ESI-MS, electrospray ionization-mass spectrometry; LC, liquid chromatography; MALDI, matrix-assisted laser desorption/ionization; MAP, multi-analyte profiling; RBM, rules based medicine; SELDI, surface enhanced laser desorption/ionization.