Figure 6.

Delayed addition of XENP345 provides robust rescue of DA neurons despite sustained microglia activation. a, Quantification of DA neuron survival after coaddition or delayed addition of XENP345 (200 ng/ml) after LPS (10 ng/ml) treatment. Values shown are mean + SEM; histogram bars with different letters are significantly different (p < 0.05). Similar results were obtained in two independent experiments. b, Quantification of microglia activation in response to LPS (10 ng/ml) in the presence or absence of XENP345 (200 ng/ml) using three different immunocytochemical microglial markers (C3R, CD45, IB4). Similar results were obtained in two independent experiments.